G6P Glucose-6-Phosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: G6Pprovided by FlyBase
Official Full Name: Glucose-6-Phosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0031463
Locus tag: Dmel_CG15400
See related: AllianceGenome:FB:FBgn0031463
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15400; Dmel\CG15400; G6pase; G6Pase; G6PC
Summary: Predicted to enable glucose-6-phosphatase activity. Involved in gluconeogenesis. Predicted to be located in endoplasmic reticulum. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in glycogen storage disease Ia; hepatocellular carcinoma; severe congenital neutropenia 4; and type 2 diabetes mellitus. Orthologous to several human genes including G6PC1 (glucose-6-phosphatase catalytic subunit 1) and G6PC2 (glucose-6-phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (2814336..2815760, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (2814336..2815760, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling.
Title: Drosophila neuronal Glucose-6-Phosphatase is a modulator of neuropeptide release that regulates muscle glycogen stores via FMRFamide signaling.

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Function	Evidence Code	Pubs
enables glucose-6-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_001097063.1

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The following sections contain reference sequences that belong to a specific genome build. Explain