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    Trmt10a tRNA methyltransferase 10A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295496, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trmt10aprovided by RGD
    Official Full Name
    tRNA methyltransferase 10Aprovided by RGD
    Primary source
    RGD:1594565
    See related
    EnsemblRapid:ENSRNOG00000011025 AllianceGenome:RGD:1594565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rg9mtd2
    Summary
    Predicted to enable tRNA (guanosine(9)-N1)-methyltransferase activity and tRNA binding activity. Predicted to be involved in tRNA N1-guanine methylation. Predicted to act upstream of or within magnesium ion homeostasis. Predicted to be located in actin cytoskeleton and nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human TRMT10A (tRNA methyltransferase 10A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 45.4), Spleen (RPKM 43.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt10a in Genome Data Viewer
    Location:
    2q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229342853..229357573)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226669445..226684166)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243422811..243437533)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 4 open reading frame 54 Neighboring gene uncharacterized LOC134485978 Neighboring gene microsomal triglyceride transfer protein Neighboring gene uncharacterized LOC134485979 Neighboring gene similar to human chromosome 4 open reading frame 17 Neighboring gene methionyl aminopeptidase 2, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. Gillis D, et al. J Med Genet, 2014 Sep. PMID 25053765
    2. tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. Igoillo-Esteve M, et al. PLoS Genet, 2013 Oct. PMID 24204302, Free PMC Article
    3. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Vilardo E, et al. Nucleic Acids Res, 2012 Dec. PMID 23042678, Free PMC Article
    4. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. White JK, et al. Cell, 2013 Jul 18. PMID 23870131, Free PMC Article
    5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116361

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA (guanosine(9)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanosine(9)-N1)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA N1-guanine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N1-guanine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 10 homolog A
    Names
    RNA (guanine-9-) methyltransferase domain containing 2
    RNA (guanine-9-)-methyltransferase domain-containing protein 2
    tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
    NP_001037697.1
    XP_017446278.1
    XP_038958037.1
    XP_038958038.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044232.1 → NP_001037697.1  tRNA methyltransferase 10 homolog A

      See identical proteins and their annotated locations for NP_001037697.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099190
      UniProtKB/Swiss-Prot
      Q4KLI2
      UniProtKB/TrEMBL
      A0A0G2K1N0, A6HW21
      Related
      ENSRNOP00000071908.3, ENSRNOT00000082894.3
      Conserved Domains (1) summary
      cd18101
      Location:101 → 276
      Trm10euk_A; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      229342853..229357573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590789.3 → XP_017446278.1  tRNA methyltransferase 10 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1N0, A0A8L2Q6X6
      Conserved Domains (1) summary
      cd18101
      Location:106 → 281
      Trm10euk_A; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A

    2. XM_039102109.1 → XP_038958037.1  tRNA methyltransferase 10 homolog A isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1N0, A0A8L2Q6X6
      Related
      ENSRNOP00000014694.6, ENSRNOT00000014694.8
      Conserved Domains (1) summary
      cd18101
      Location:106 → 281
      Trm10euk_A; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A

    3. XM_039102110.2 → XP_038958038.1  tRNA methyltransferase 10 homolog A isoform X2

      UniProtKB/Swiss-Prot
      Q4KLI2
      UniProtKB/TrEMBL
      A0A0G2K1N0, A6HW21
      Conserved Domains (1) summary
      cd18101
      Location:101 → 276
      Trm10euk_A; eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLI2.1 GenPept UniProtKB/Swiss-Prot:Q4KLI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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