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    muc midline uncoordinated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34021, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mucprovided by FlyBase
    Official Full Name
    midline uncoordinatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0283658
    Locus tag
    Dmel_CG5261
    See related
    AllianceGenome:FB:FBgn0283658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.121; CG5261; DLAT; Dmel\CG5261; EP(2)0816; EP816; PDH-E2
    Summary
    Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Involved in grooming behavior. Predicted to be located in mitochondrion. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human DLAT (dihydrolipoamide S-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See muc in Genome Data Viewer
    Location:
    27F4-27F4; 2-26 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7426866..7430329)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7426866..7430329)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43857 Neighboring gene mir-275 stem loop Neighboring gene mir-305 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scavenger receptor acting in neural tissue and majority of rhodopsin is absent

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. Schell JC, et al. Nat Cell Biol, 2017 Sep. PMID 28812582, Free PMC Article
    2. Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. Foronda D, et al. Genes Dev, 2014 Nov 1. PMID 25367037, Free PMC Article
    3. Evidence of spatially varying selection acting on four chromatin-remodeling loci in Drosophila melanogaster. Levine MT, et al. Genetics, 2008 May. PMID 18245821, Free PMC Article
    4. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
    5. Neuronal specificity and its development in the Drosophila wing disc and its derivatives. Palka J. J Neurobiol, 1993 Jun. PMID 8331339

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dihydrolipoyllysine-residue acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydrolipoyllysine-residue acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to pyruvate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of pyruvate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pyruvate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pyruvate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    midline uncoordinated
    Names
    CG5261-PA
    CG5261-PB
    CG5261-PC
    CG5261-PD
    CG5261-PE
    CG5261-PF
    Dihydrolipoyllysine-residue acetyltransferase
    muc-PA
    muc-PB
    muc-PC
    muc-PD
    muc-PE
    muc-PF
    NP_001260193.1
    NP_001260194.1
    NP_001260195.1
    NP_001260196.1
    NP_609118.1
    NP_723274.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      7426866..7430329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135274.2 → NP_609118.1  midline uncoordinated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609118.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM13, Q9VM14
      Related
      FBpp0079072, FBtr0079444
      Conserved Domains (3) summary
      cd06849
      Location:83 → 155
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:83 → 512
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:299 → 512
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    2. NM_001273267.1 → NP_001260196.1  midline uncoordinated, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VM13, Q9VM14
      Conserved Domains (3) summary
      cd06849
      Location:83 → 155
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:83 → 512
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:299 → 512
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    3. NM_001273266.1 → NP_001260195.1  midline uncoordinated, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260195.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCG1
      Conserved Domains (3) summary
      cd06849
      Location:83 → 155
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:83 → 496
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:283 → 496
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    4. NM_001273265.1 → NP_001260194.1  midline uncoordinated, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260194.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCU4
      Conserved Domains (3) summary
      cd06849
      Location:83 → 155
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:83 → 489
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:276 → 489
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    5. NM_001273264.1 → NP_001260193.1  midline uncoordinated, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260193.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCA2
      Conserved Domains (3) summary
      cd06849
      Location:83 → 155
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:83 → 473
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:260 → 473
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

    6. NM_164749.1 → NP_723274.1  midline uncoordinated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723274.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTK9
      Related
      FBpp0079073, FBtr0079445
      Conserved Domains (3) summary
      cd06849
      Location:1 → 64
      lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
      TIGR01349
      Location:1 → 421
      PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
      pfam00198
      Location:208 → 421
      2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCA2 M9PCA2
    M9PCG1 M9PCG1
    M9PCU4 M9PCU4
    Q7KTK9 Q7KTK9
    Q9VM14 Q9VM14

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