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    Fezf2 Fez family zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305719, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fezf2provided by RGD
    Official Full Name
    Fez family zinc finger 2provided by RGD
    Primary source
    RGD:1311068
    See related
    EnsemblRapid:ENSRNOG00000009206 AllianceGenome:RGD:1311068
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp312
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including cell dedifferentiation; positive regulation of DNA-templated transcription; and regulation of neurogenesis. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; nervous system development; and regulation of neuron differentiation. Predicted to be located in nucleus. Orthologous to human FEZF2 (FEZ family zinc finger 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 21.8) and Thymus (RPKM 7.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fezf2 in Genome Data Viewer
    Location:
    15p15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (15199045..15207982)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (12768614..12777554)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (12825333..12831496)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene calcium dependent secretion activator Neighboring gene Histone deacetylase 1, pseudogene 3 Neighboring gene ribosomal protein S27, pseudogene 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene centrosomal protein 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. Chen JG, et al. Proc Natl Acad Sci U S A, 2005 Dec 6. PMID 16314561, Free PMC Article
    2. Zinc finger gene fez-like functions in the formation of subplate neurons and thalamocortical axons. Hirata T, et al. Dev Dyn, 2004 Jul. PMID 15188439
    3. dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Weng M, et al. Dev Cell, 2010 Jan 19. PMID 20152183, Free PMC Article
    4. A network of genetic repression and derepression specifies projection fates in the developing neocortex. Srinivasan K, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23144223, Free PMC Article
    5. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Lodato S, et al. Neuron, 2011 Feb 24. PMID 21338885, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of GABAergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axonal fasciculation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell dedifferentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within commitment of neuronal cell to specific neuron type in forebrain ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dentate gyrus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within forebrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron fate determination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telencephalon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fez family zinc finger protein 2
    Names
    zinc finger protein 312

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107251.1 → NP_001100721.1  fez family zinc finger protein 2

      See identical proteins and their annotated locations for NP_001100721.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474010
      UniProtKB/TrEMBL
      A6K089, B4F7C0, F7ERI8
      Related
      ENSRNOP00000012452.4, ENSRNOT00000012452.7
      Conserved Domains (4) summary
      COG5048
      Location:284 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380 → 436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317 → 339
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      15199045..15207982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093243.2 → XP_038949171.1  fez family zinc finger protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K089, B4F7C0, F7ERI8
      Conserved Domains (4) summary
      COG5048
      Location:284 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380 → 436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317 → 339
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039093242.2 → XP_038949170.1  fez family zinc finger protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K089, B4F7C0, F7ERI8
      Conserved Domains (4) summary
      COG5048
      Location:284 → 390
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:380 → 436
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:317 → 339
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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