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    Rita1 RBPJ interacting and tubulin associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rita1provided by RGD
    Official Full Name
    RBPJ interacting and tubulin associated 1provided by RGD
    Primary source
    RGD:1306772
    See related
    EnsemblRapid:ENSRNOG00000037720 AllianceGenome:RGD:1306772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rita; RGD1306772
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; neurogenesis; and nuclear export. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human RITA1 (RBPJ interacting and tubulin associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 83.4), Muscle (RPKM 71.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rita1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41610713..41614545)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35950090..35953960)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41484970..41488889)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A1, pseudogene 2 Neighboring gene cilia and flagella associated protein 73 Neighboring gene DEAD-box helicase 54 Neighboring gene IQ motif containing D Neighboring gene uncharacterized LOC120095848 Neighboring gene two pore segment channel 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. Wacker SA, et al. EMBO J, 2011 Jan 5. PMID 21102556, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nuclear export IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RBPJ-interacting and tubulin-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044226.1 → NP_001037691.1  RBPJ-interacting and tubulin-associated protein 1

      See identical proteins and their annotated locations for NP_001037691.1

      Status: PROVISIONAL

      Source sequence(s)
      BC112384
      UniProtKB/Swiss-Prot
      Q2KJ10
      UniProtKB/TrEMBL
      A6J1I6
      Related
      ENSRNOP00000054067.2, ENSRNOT00000057242.4
      Conserved Domains (1) summary
      pfam17066
      Location:1 → 258
      RITA; RBPJ-interacting and tubulin associated protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      41610713..41614545
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249383.5 → XP_006249445.1  RBPJ-interacting and tubulin-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249445.1

      UniProtKB/Swiss-Prot
      Q2KJ10
      UniProtKB/TrEMBL
      A6J1I6
      Conserved Domains (1) summary
      pfam17066
      Location:1 → 258
      RITA; RBPJ-interacting and tubulin associated protein

    2. XM_006249384.5 → XP_006249446.1  RBPJ-interacting and tubulin-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249446.1

      UniProtKB/Swiss-Prot
      Q2KJ10
      UniProtKB/TrEMBL
      A6J1I6
      Conserved Domains (1) summary
      pfam17066
      Location:1 → 258
      RITA; RBPJ-interacting and tubulin associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2KJ10.1 GenPept UniProtKB/Swiss-Prot:Q2KJ10

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