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    Rps15 ribosomal protein S15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29285, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rps15provided by RGD
    Official Full Name
    ribosomal protein S15provided by RGD
    Primary source
    RGD:62026
    See related
    EnsemblRapid:ENSRNOG00000024603 AllianceGenome:RGD:62026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    A structural constituent of ribosome. Involved in liver regeneration and ribosomal small subunit assembly. Located in nucleoplasm. Part of cytosolic small ribosomal subunit. Is active in synapse. Biomarker of insulinoma. Orthologous to human RPS15 (ribosomal protein S15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 3948.6), Thymus (RPKM 3307.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps15 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10066572..10068167, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9416003..9417442, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12282134..12283573, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351405 Neighboring gene proprotein convertase subtilisin/kexin type 4 Neighboring gene similar to human chromosome 19 open reading frame 25 Neighboring gene APC regulator of WNT signaling pathway 2 Neighboring gene DAZ associated protein 1 Neighboring gene guanidinoacetate N-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The primary structure of rat rig/ribosomal protein S15 gene. Takasawa S, et al. Biochim Biophys Acta, 1992 Sep 24. PMID 1390896
    2. Expression of the insulinoma gene rig during liver regeneration and in primary cultured hepatocytes. Inoue C, et al. Biochem Biophys Res Commun, 1988 Feb 15. PMID 2829897
    3. Novel gene activated in rat insulinomas. Takasawa S, et al. Diabetes, 1986 Oct. PMID 3019805
    4. rig encodes ribosomal protein S15. The primary structure of mammalian ribosomal protein S15. Kitagawa M, et al. FEBS Lett, 1991 Jun 3. PMID 2044758
    5. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. Rouquette J, et al. EMBO J, 2005 Aug 17. PMID 16037817, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS19
    Names
    40S ribosomal protein S15
    RIG protein
    insulinoma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017151.2 → NP_058847.1  small ribosomal subunit protein uS19

      See identical proteins and their annotated locations for NP_058847.1

      Status: VALIDATED

      Source sequence(s)
      AA892895, AI603168, M19393
      UniProtKB/Swiss-Prot
      P62845
      UniProtKB/TrEMBL
      A6K8N0, D3ZAK6
      Related
      ENSRNOP00000035156.3, ENSRNOT00000029791.6
      Conserved Domains (1) summary
      PTZ00096
      Location:1 → 143
      PTZ00096; 40S ribosomal protein S15; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10066572..10068167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263115.1 → XP_063119185.1  small ribosomal subunit protein uS19 isoform X2

    2. XM_063263114.1 → XP_063119184.1  small ribosomal subunit protein uS19 isoform X1

    3. XM_063263116.1 → XP_063119186.1  small ribosomal subunit protein uS19 isoform X3

      Related
      ENSRNOP00000092210.1, ENSRNOT00000113730.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62845.2 GenPept UniProtKB/Swiss-Prot:P62845

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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