Polr1D RNA polymerase I and III subunit D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Polr1Dprovided by FlyBase
Official Full Name: RNA polymerase I and III subunit Dprovided by FlyBase
Primary source: FLYBASE:FBgn0086447
Locus tag: Dmel_CG10685
See related: AllianceGenome:FB:FBgn0086447
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC19; Cg; CG10685; Dmel\CG10685; l(2)37Cg; RPC19
Summary: Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19133023..19135233, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19133023..19135233, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA-directed 5'-3' RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to RNA polymerase I activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase I activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase III activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info

Names: CG10685-PA; CG10685-PC; CG10685-PD; Polr1D-PA; Polr1D-PC; Polr1D-PD; lethal (2) 37Cg

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