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    sick sickie [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35277, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sickprovided by FlyBase
    Official Full Name
    sickieprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263873
    Locus tag
    Dmel_CG43720
    See related
    AllianceGenome:FB:FBgn0263873
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10662; CG13958; CG13959; CG13960; CG13961; CG13964; CG33316; CG34343; CG42589; CG43720; Dmel\CG43720; Dm_2L:104545
    Old locus tag
    CG10662; CG33316; Dmel_CG10662; Dmel_CG13958; Dmel_CG13964; Dmel_CG33316; Dmel_CG34343; Dmel_CG42589
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in several processes, including actin filament organization; defense response to Gram-negative bacterium; and positive regulation of peptidoglycan recognition protein signaling pathway. Is expressed in several structures, including adult heart; alpha/beta Kenyon cell; brain; larval imaginal tissue; and sensory nervous system primordium. Used to study cerebellar hypoplasia. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to several human genes including NAV2 (neuron navigator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sick in Genome Data Viewer
    Location:
    38A3-38A8; 2-54 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19796365..19958424)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19796365..19958424)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Cd GTPase activating protein-related Neighboring gene female sterile (2) ltoPP43 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 38AB a Neighboring gene small nuclear RNA U2 at 38AB b Neighboring gene small nuclear RNA U4 at 38AB Neighboring gene small nuclear RNA U2 at 38AB a Neighboring gene small nuclear RNA U5 at 38AB b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43097 Neighboring gene long non-coding RNA:CR43828 Neighboring gene long non-coding RNA:CR43827 Neighboring gene long non-coding RNA:CR45183 Neighboring gene Turandot F Neighboring gene Turandot E Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of Neuron Navigator 2 Impairs Brain and Cerebellar Development. Accogli A, et al. Cerebellum, 2023 Apr. PMID 35218524, Free PMC Article
    2. The Neuron Navigators: Structure, function, and evolutionary history. Powers RM, et al. Front Mol Neurosci, 2022. PMID 36710926, Free PMC Article
    3. Active forgetting requires Sickie function in a dedicated dopamine circuit in Drosophila. Zhang X, et al. Proc Natl Acad Sci U S A, 2022 Sep 20. PMID 36095217, Free PMC Article
    4. Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster. Behrman EL, et al. Proc Biol Sci, 2018 Jan 10. PMID 29321302, Free PMC Article
    5. The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway. Abe T, et al. Development, 2014 Dec. PMID 25411210

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Active forgetting requires Sickie function in a dedicated dopamine circuit in Drosophila.
      Title: Active forgetting requires Sickie function in a dedicated dopamine circuit in Drosophila.
    2. RNAi knockdown sickie enhances olfactory memory through effects in dopaminergic neurons without apparent effects on acquisition.
      Title: Identification of genes that promote or inhibit olfactory memory formation in Drosophila.
    3. Sickie regulates F-actin-mediated axonal growth via the non-canonical Rac-Cofilin pathway in a Slingshot-dependent manner.
      Title: The NAV2 homolog Sickie regulates F-actin-mediated axonal growth in Drosophila mushroom body neurons via the non-canonical Rac-Cofilin pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 19813239-19813515 mobile_element_type = transposon:INE-1{}4025
    • Loc: 19816785-19816819 mobile_element_type = transposon:INE-1{}4026

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sickie
    Names
    CG43720-PB
    CG43720-PD
    CG43720-PE
    CG43720-PF
    CG43720-PG
    CG43720-PH
    CG43720-PI
    CG43720-PJ
    CG43720-PK
    CG43720-PL
    CG43720-PM
    CG43720-PN
    sick-PB
    sick-PD
    sick-PE
    sick-PF
    sick-PG
    sick-PH
    sick-PI
    sick-PJ
    sick-PK
    sick-PL
    sick-PM
    sick-PN

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19796365..19958424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273674.1 → NP_001260603.1  sickie, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260603.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBE4
      Conserved Domains (4) summary
      smart00033
      Location:21 → 122
      CH; Calponin homology domain
      smart00382
      Location:1867 → 2016
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1870 → 1961
      AAA_22; AAA domain
      pfam15688
      Location:240 → 332
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

    2. NM_206008.4 → NP_995730.2  sickie, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995730.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VIQ9
      Conserved Domains (4) summary
      smart00033
      Location:5 → 106
      CH; Calponin homology domain
      smart00382
      Location:1851 → 2000
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1854 → 1945
      AAA_22; AAA domain
      pfam15688
      Location:224 → 316
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

    3. NM_001273678.1 → NP_001260607.1  sickie, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260607.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA0
      Conserved Domains (3) summary
      smart00033
      Location:535 → 637
      CH; Calponin homology domain
      smart00382
      Location:2382 → 2531
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:2385 → 2476
      AAA_22; AAA domain

    4. NM_001273677.1 → NP_001260606.1  sickie, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260606.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA0
      Conserved Domains (3) summary
      smart00033
      Location:535 → 637
      CH; Calponin homology domain
      smart00382
      Location:2382 → 2531
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:2385 → 2476
      AAA_22; AAA domain

    5. NM_001273680.2 → NP_001260609.1  sickie, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD86
      Conserved Domains (4) summary
      smart00033
      Location:25 → 127
      CH; Calponin homology domain
      smart00382
      Location:1881 → 2030
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1884 → 1975
      AAA_22; AAA domain
      pfam15688
      Location:245 → 337
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

    6. NM_206007.5 → NP_995729.2  sickie, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995729.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KT30, Q7KT31, Q9VIQ9
      Conserved Domains (4) summary
      smart00033
      Location:25 → 127
      CH; Calponin homology domain
      smart00382
      Location:1872 → 2021
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1875 → 1966
      AAA_22; AAA domain
      pfam15688
      Location:245 → 337
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

    7. NM_001273681.1 → NP_001260610.1  sickie, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS6
      Conserved Domains (3) summary
      smart00382
      Location:1668 → 1817
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1671 → 1762
      AAA_22; AAA domain
      pfam15688
      Location:41 → 133
      NRIP1_repr_2; Nuclear receptor-interacting protein 1 repression 2

    8. NM_001273676.1 → NP_001260605.1  sickie, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS2
      Conserved Domains (2) summary
      smart00382
      Location:1693 → 1842
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1696 → 1787
      AAA_22; AAA domain

    9. NM_001103713.4 → NP_001097183.1  sickie, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097183.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDS2
      Conserved Domains (2) summary
      smart00382
      Location:1693 → 1842
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1696 → 1787
      AAA_22; AAA domain

    10. NM_001273679.1 → NP_001260608.1  sickie, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260608.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBE5
      Conserved Domains (3) summary
      smart00382
      Location:1044 → 1193
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1047 → 1138
      AAA_22; AAA domain
      cl19863
      Location:657 → 768
      DUF935; Protein of unknown function (DUF935)

    11. NM_001273675.1 → NP_001260604.1  sickie, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260604.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIR0
      Conserved Domains (2) summary
      smart00382
      Location:1021 → 1170
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1024 → 1115
      AAA_22; AAA domain

    12. NM_136167.3 → NP_610011.2  sickie, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610011.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIR0
      Conserved Domains (2) summary
      smart00382
      Location:1021 → 1170
      AAA; ATPases associated with a variety of cellular activities
      pfam13401
      Location:1024 → 1115
      AAA_22; AAA domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBE4 M9PBE4
    M9PBE5 M9PBE5
    M9PD86 M9PD86
    M9PDS2 M9PDS2
    M9PDS6 M9PDS6
    M9PGA0 M9PGA0
    Q8MR85 Q8MR85
    Q9VIQ9.3 Q9VIQ9
    Q9VIR0 Q9VIR0

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