Acot2 acyl-CoA thioesterase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acot2provided by RGD
Official Full Name: acyl-CoA thioesterase 2provided by RGD
Primary source: RGD:621055
See related: EnsemblRapid:ENSRNOG00000010134 AllianceGenome:RGD:621055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mte1
Summary: Enables long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including long-chain fatty-acyl-CoA catabolic process; response to epidermal growth factor; and response to hypoxia. Predicted to be located in mitochondrion. Used to study type 2 diabetes mellitus. Orthologous to human ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 471.6), Kidney (RPKM 274.4) and 9 other tissues See more
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Genomic context

Location:: 6q31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (109341426..109352818)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (103611738..103619404)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (107460596..107468324)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACOT isoform expression may be regulated during brown adipocyte differentiation to support the fat storage and combustion characteristics of this cell type.
Title: Regulated expression of acyl-CoA thioesterases in the differentiation of cultured rat brown adipocytes.
High-fat feeding, fasting, and experimental diabetes, interventions that increase FA availability, muscle PPAR alpha activity, and muscle fatty acid oxidation rates, increased mitochondrial thioesterase 1 mRNA in heart and soleus muscle.
Title: Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle.

Submit: New GeneRIF Correction

General gene information

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Markers

BE101215 (e-PCR)
- UniSTS:243535

RH128388 (e-PCR)
- UniSTS:211696

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty-acyl-CoA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to epidermal growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase 2, mitochondrial

Names: ARTISt/p43; MTE-I; acyl coenzyme A thioester hydrolase; mitochondrial acyl-CoA thioesterase 1; very-long-chain acyl-CoA thioesterase

NP_620262.2

EC 3.1.2.2

XP_006240382.1

EC 3.1.2.2

XP_063117607.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138907.3 → NP_620262.2 acyl-coenzyme A thioesterase 2, mitochondrial

See identical proteins and their annotated locations for NP_620262.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O55171, O88268

UniProtKB/TrEMBL

A6JDS4, F7F6S1, Q6IMX8

Related

ENSRNOP00000013515.4, ENSRNOT00000013515.7

Conserved Domains (3) summary

pfam04775
Location:58 → 178

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:244 → 451

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

cl21494
Location:186 → 298

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

109341426..109352818

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240320.5 → XP_006240382.1 acyl-coenzyme A thioesterase 2, mitochondrial isoform X1

UniProtKB/Swiss-Prot

O55171, O88268

UniProtKB/TrEMBL

A0A8I6A1M5

Related

ENSRNOP00000086137.1, ENSRNOT00000115016.2

Conserved Domains (3) summary

pfam04775
Location:58 → 178

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

pfam08840
Location:244 → 450

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

cl21494
Location:186 → 298

Abhydrolase; alpha/beta hydrolases
XM_063261537.1 → XP_063117607.1 acyl-coenzyme A thioesterase 2, mitochondrial isoform X2