Zasp52 Z band alternatively spliced PDZ-motif protein 52 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Zasp52provided by FlyBase
Official Full Name: Z band alternatively spliced PDZ-motif protein 52provided by FlyBase
Primary source: FLYBASE:FBgn0265991
Locus tag: Dmel_CG30084
See related: AllianceGenome:FB:FBgn0265991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12968; CG12969; CG30084; CG8242; Dmel\CG30084; dzasp; tun; Z(210); zasp; Zasp; ZASP; zasp52; ZASP52; Zbp210
Summary: Enables actin binding activity and muscle alpha-actinin binding activity. Involved in myofibril assembly and regulation of cell-matrix adhesion. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and muscle tendon junction. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; gut section; muscle cell; and somatic muscle. Used to study myofibrillar myopathy 4. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to several human genes including PDLIM5 (PDZ and LIM domain 5) and PDLIM7 (PDZ and LIM domain 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52C4-52C7; 2-75 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (15762565..15817004, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (11650070..11704509, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.
Title: Characterizing the actin-binding ability of Zasp52 and its contribution to myofibril assembly.
Here the authors show that the PDZ and LIM domain protein Zasp, a structural component of Z-discs, mediates Z-disc and thereby myofibril growth through protein oligomerization.
Title: Myofibril diameter is set by a finely tuned mechanism of protein oligomerization in Drosophila.
Flight assays also show that a Zasp52 mutant suppresses the a-actinin mutant phenotype, indicating that both proteins are core structural Z-disc proteins required for optimal Z-disc function.
Title: Zasp52, a Core Z-disc Protein in Drosophila Indirect Flight Muscles, Interacts with α-Actinin via an Extended PDZ Domain.
analysis of Zasp52 nonmuscle expression and epithelial apicobasal localization
Title: Extensive nonmuscle expression and epithelial apicobasal localization of the Drosophila ALP/Enigma family protein, Zasp52.
Zasp is the first protein shown to co-activate alpha5beta1 integrins with talin and appears to do so in a manner distinct from known alphaIIbbeta3 integrin co-activators.
Title: Zasp regulates integrin activation.
Zasp52 and Zasp66 directly bind to alpha-actinin, and they can also form a ternary complex.
Title: Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly.
Zasp52 is required for the association of alpha-actinin with the flight muscle Z-disc, and for normal sarcomere structure.
Title: The Drosophila Z-disc protein Z(210) is an adult muscle isoform of Zasp52, which is required for normal myofibril organization in indirect flight muscles.
stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains.
Title: Muscle type-specific expression of Zasp52 isoforms in Drosophila.
Transcriptional analysis of dzasp has revealed six additional exons, with respect to the known 16, and multiple splice variants
Title: Post-transcriptional silencing of the Drosophila homolog of human ZASP: a molecular and functional analysis.
Our observations point to an important function for Zasp in the assembly of integrin adhesion sites both in cell culture and in tissues.
Title: Zasp is required for the assembly of functional integrin adhesion sites.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables actinin binding	IPI Inferred from Physical Interaction more info	PubMed
enables muscle alpha-actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables muscle alpha-actinin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables muscle alpha-actinin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle structure development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Z band alternatively spliced PDZ-motif protein 52

Names: CG30084-PAA; CG30084-PC; CG30084-PE; CG30084-PF; CG30084-PG; CG30084-PI; CG30084-PK; CG30084-PL; CG30084-PM; CG30084-PN; CG30084-PO; CG30084-PP; CG30084-PQ; CG30084-PR; CG30084-PS; CG30084-PT; CG30084-PU; CG30084-PV; CG30084-PW; CG30084-PX; CG30084-PY; CG30084-PZ; Z band alternatively spliced PDZ-motif containing protein 52; Z band alternatively spliced PDZ-motif protein; Z-band-protein-210; Zasp52-PAA; Zasp52-PC; Zasp52-PE; Zasp52-PF; Zasp52-PG; Zasp52-PI; Zasp52-PK; Zasp52-PL; Zasp52-PM; Zasp52-PN; Zasp52-PO; Zasp52-PP; Zasp52-PQ; Zasp52-PR; Zasp52-PS; Zasp52-PT; Zasp52-PU; Zasp52-PV; Zasp52-PW; Zasp52-PX; Zasp52-PY; Zasp52-PZ; tungus; zetalin

NP_001027420.2

EC 3.4.24.-

NP_001027421.1

EC 3.4.24.-

NP_001036551.1

EC 3.4.24.-

NP_001163163.1

EC 3.4.24.-

NP_001261005.1

EC 3.4.24.-

NP_001261006.1

EC 3.4.24.-

NP_001261007.1

EC 3.4.24.-

NP_001261008.1

EC 3.4.24.-

NP_001261009.1

EC 3.4.24.-

NP_001261010.1

EC 3.4.24.-

NP_001261011.1

EC 3.4.24.-

NP_001261012.1

EC 3.4.24.-

NP_001261013.1

EC 3.4.24.-

NP_001261014.1

EC 3.4.24.-

NP_001261015.1

EC 3.4.24.-

NP_001286467.1

EC 3.4.24.-

NP_001303350.1

EC 3.4.24.-

NP_001303351.1

EC 3.4.24.-

NP_001303352.1

EC 3.4.24.-

NP_001369093.1

EC 3.4.24.-

NP_611058.4

EC 3.4.24.-

NP_665700.2

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

15762565..15817004 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_145757.3 → NP_665700.2 Z band alternatively spliced PDZ-motif protein 52, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_665700.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZA47

Conserved Domains (6) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:908 → 961

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1028 → 1081

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:969 → 1020

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001316421.1 → NP_001303350.1 Z band alternatively spliced PDZ-motif protein 52, isoform X [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUN6

Conserved Domains (6) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1968 → 2021

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:2088 → 2141

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:2029 → 2080

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001032250.3 → NP_001027421.1 Z band alternatively spliced PDZ-motif protein 52, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027421.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZA47

Conserved Domains (6) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:606 → 659

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:726 → 779

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:667 → 718

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274078.1 → NP_001261007.1 Z band alternatively spliced PDZ-motif protein 52, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261007.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KER6

Conserved Domains (6) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1093 → 1146

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1213 → 1266

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:1154 → 1205

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001043086.3 → NP_001036551.1 Z band alternatively spliced PDZ-motif protein 52, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036551.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZA47

Conserved Domains (6) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:716 → 769

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:836 → 889

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:777 → 828

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274086.1 → NP_001261015.1 Z band alternatively spliced PDZ-motif protein 52, isoform V [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261015.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX32

Conserved Domains (6) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:781 → 834

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:901 → 954

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:842 → 893

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274084.1 → NP_001261013.1 Z band alternatively spliced PDZ-motif protein 52, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261013.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX29

Conserved Domains (6) summary

cd09455
Location:477 → 530

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:597 → 650

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:538 → 589

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:282 → 333

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001274085.1 → NP_001261014.1 Z band alternatively spliced PDZ-motif protein 52, isoform U [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261014.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX30

Conserved Domains (6) summary

cd09455
Location:542 → 595

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:662 → 715

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:603 → 654

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:282 → 333

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001274077.1 → NP_001261006.1 Z band alternatively spliced PDZ-motif protein 52, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261006.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEW3

Conserved Domains (6) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1144 → 1197

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1264 → 1317

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:1205 → 1256

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001299538.1 → NP_001286467.1 Z band alternatively spliced PDZ-motif protein 52, isoform W [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286467.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGL0

Conserved Domains (7) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1910 → 1963

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:2030 → 2083

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

PHA03247
Location:652 → 896

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:1971 → 2022

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 218

DUF4749; Domain of unknown function (DUF4749)
NM_001274082.1 → NP_001261011.1 Z band alternatively spliced PDZ-motif protein 52, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261011.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX27

Conserved Domains (6) summary

cd09455
Location:548 → 601

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:668 → 721

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:609 → 660

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:282 → 333

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001274083.1 → NP_001261012.1 Z band alternatively spliced PDZ-motif protein 52, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261012.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX28

Conserved Domains (6) summary

cd09455
Location:613 → 666

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:733 → 786

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:674 → 725

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:282 → 333

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001032249.4 → NP_001027420.2 Z band alternatively spliced PDZ-motif protein 52, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001027420.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZA47, A1ZA48, A1ZA49, A8DYF3, B0EW00, Q4V6Y5, Q6NNA6, Q86NZ1, Q8IGJ7

Conserved Domains (6) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:2020 → 2073

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:2140 → 2193

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:2081 → 2132

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274076.1 → NP_001261005.1 Z band alternatively spliced PDZ-motif protein 52, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261005.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFR8

Conserved Domains (6) summary

cd09455
Location:723 → 776

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:843 → 896

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:784 → 835

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:282 → 333

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_137214.5 → NP_611058.4 Z band alternatively spliced PDZ-motif protein 52, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611058.4

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZA47

Conserved Domains (6) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd09455
Location:1096 → 1150

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1217 → 1270

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd08368
Location:1158 → 1209

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274081.1 → NP_001261010.1 Z band alternatively spliced PDZ-motif protein 52, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261010.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX33

Conserved Domains (3) summary

cd09455
Location:1584 → 1637

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:1704 → 1757

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd08368
Location:1645 → 1696

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001316422.1 → NP_001303351.1 Z band alternatively spliced PDZ-motif protein 52, isoform Y [Drosophila melanogaster]

Status: REVIEWED

Conserved Domains (3) summary

cd09455
Location:222 → 275

LIM1_Enigma_like_1; The first LIM domain of an Enigma subfamily with unknown function

cd09461
Location:342 → 395

LIM3_Enigma_like_1; The third LIM domain of an Enigma subfamily with unknown function

cd08368
Location:283 → 334

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001316423.1 → NP_001303352.1 Z band alternatively spliced PDZ-motif protein 52, isoform Z [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

C1C3E7

Conserved Domains (3) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001169692.2 → NP_001163163.1 Z band alternatively spliced PDZ-motif protein 52, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163163.1

Status: REVIEWED

UniProtKB/TrEMBL

C1C3E7

Conserved Domains (3) summary

cd09360
Location:282 → 333

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274079.1 → NP_001261008.1 Z band alternatively spliced PDZ-motif protein 52, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261008.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX31

Conserved Domains (3) summary

cd09360
Location:340 → 391

LIM_ALP_like; The LIM domain of ALP (actinin-associated LIM protein) family

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:150 → 217

DUF4749; Domain of unknown function (DUF4749)
NM_001274080.1 → NP_001261009.1 Z band alternatively spliced PDZ-motif protein 52, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261009.1

Status: REVIEWED

UniProtKB/TrEMBL

G3JX25

Conserved Domains (2) summary

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:150 → 227

DUF4749; Domain of unknown function (DUF4749)
NM_001382054.1 → NP_001369093.1 Z band alternatively spliced PDZ-motif protein 52, isoform AA [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3Q9H2

Conserved Domains (2) summary

cd00992
Location:6 → 87

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:150 → 216

DUF4749; Domain of unknown function (DUF4749)

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KER6		A0A0B4KER6
A0A0B4KEW3		A0A0B4KEW3
A0A0B4KFR8		A0A0B4KFR8
A0A0B4LGL0		A0A0B4LGL0
A0A126GUN6		A0A126GUN6
A0A6M3Q9H2		A0A6M3Q9H2
A1ZA47.2		A1ZA47
C1C3E7		C1C3E7
G3JX25		G3JX25
G3JX27		G3JX27
G3JX28		G3JX28
G3JX29		G3JX29
G3JX30		G3JX30
G3JX31		G3JX31
G3JX32		G3JX32
G3JX33		G3JX33