Emc10 ER membrane protein complex subunit 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Emc10provided by RGD
Official Full Name: ER membrane protein complex subunit 10provided by RGD
Primary source: RGD:1303214
See related: EnsemblRapid:ENSRNOG00000019532 AllianceGenome:RGD:1303214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Inm02
Summary: Predicted to contribute to membrane insertase activity. Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane and extracellular region. Predicted to be part of EMC complex. Orthologous to human EMC10 (ER membrane protein complex subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 167.4), Kidney (RPKM 156.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (104119040..104125409, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94980260..94988847, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100495112..100501468, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

as a novel secreted protein, INM02 (MGC93975) is associated with functions of pancreatic islets, especially of beta-cells
Title: Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135163 (e-PCR)
- UniSTS:218440

RH140214 (e-PCR)
- UniSTS:222293

RH127490 (e-PCR)
- UniSTS:210800

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables membrane insertase activity	IEA Inferred from Electronic Annotation more info
contributes_to membrane insertase activity	ISO Inferred from Sequence Orthology more info
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in tail-anchored membrane protein insertion into ER membrane	IEA Inferred from Electronic Annotation more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	IEA Inferred from Electronic Annotation more info
part_of EMC complex	ISO Inferred from Sequence Orthology more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ER membrane protein complex subunit 10

Names: UPF0510 protein INM02

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.