Pcbp2 poly(rC) binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pcbp2provided by RGD
Official Full Name: poly(rC) binding protein 2provided by RGD
Primary source: RGD:1309626
See related: EnsemblRapid:ENSRNOG00000036852 AllianceGenome:RGD:1309626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nucleic acid binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including IRES-dependent viral translational initiation; chromatin looping; and regulation of defense response. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Is active in postsynaptic density. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 199.1), Thymus (RPKM 177.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135483702..135508254)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133605375..133631312)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144077901..144103723)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
Title: PCBP2 knockdown promotes ferroptosis in malignant mesothelioma.
PCBP2 might play important roles in central nervous system pathophysiology after spinal cord injury
Title: PCBP2 Modulates Neural Apoptosis and Astrocyte Proliferation After Spinal Cord Injury.
that the change of poly(C)-binding proteins protein expression was associated with Schwann cell proliferation after the trauma of the peripheral nervous system
Title: Spatiotemporal Expression of Poly(rC)-Binding Protein PCBP2 Modulates Schwann Cell Proliferation After Sciatic Nerve Injury.
The localization of PCBP proteins to TH-positive cells in these catecholaminergic tissues is consistent with the hypothesis that PCBPs play a role in the regulation of TH expression.
Title: Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain.
This study provides the first evidence that alcohol up-regulates the expression of PCBP2, which subsequently increases the half-life of collagen alpha1(I)mRNA.
Title: PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF389691 (e-PCR)
- UniSTS:245511

AW412548 (e-PCR)
- UniSTS:180842

UniSTS:479190 (e-PCR)
- UniSTS:479190

Pcbp2 (e-PCR), detects polymorphism
- UniSTS:479190

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-rich single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-enhancer loop anchoring activity	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin looping	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral RNA genome replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: poly(rC)-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013223.2 → NP_001013241.1 poly(rC)-binding protein 2

See identical proteins and their annotated locations for NP_001013241.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2KBC5, D4ACH3, Q6AYU5

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:284 → 359

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

135483702..135508254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242420.4 → XP_006242482.1 poly(rC)-binding protein 2 isoform X21

See identical proteins and their annotated locations for XP_006242482.1

UniProtKB/TrEMBL

A0A0G2KBC5

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:280 → 355

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263971.1 → XP_063120041.1 poly(rC)-binding protein 2 isoform X8
XM_017595011.3 → XP_017450500.1 poly(rC)-binding protein 2 isoform X9

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:250 → 325

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_017595010.3 → XP_017450499.1 poly(rC)-binding protein 2 isoform X9

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:250 → 325

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263972.1 → XP_063120042.1 poly(rC)-binding protein 2 isoform X10
XM_017595006.3 → XP_017450495.1 poly(rC)-binding protein 2 isoform X3

Related

ENSRNOP00000095172.2, ENSRNOT00000120216.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263978.1 → XP_063120048.1 poly(rC)-binding protein 2 isoform X14
XM_039079651.2 → XP_038935579.1 poly(rC)-binding protein 2 isoform X30

UniProtKB/TrEMBL

A0A0G2KBC5

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:249 → 324

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263994.1 → XP_063120064.1 poly(rC)-binding protein 2 isoform X29

UniProtKB/TrEMBL

A0A8I6AP00, A6KCV9
XM_006242419.5 → XP_006242481.1 poly(rC)-binding protein 2 isoform X20

See identical proteins and their annotated locations for XP_006242481.1

UniProtKB/TrEMBL

A0A0G2KBC5, A0A8I5ZS12, Q6AYU2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_006242425.4 → XP_006242487.1 poly(rC)-binding protein 2 isoform X29

See identical proteins and their annotated locations for XP_006242487.1

UniProtKB/TrEMBL

A0A0G2KBC5, A0A8I6AP00, A6KCV9

Related

ENSRNOP00000095661.2, ENSRNOT00000099581.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:250 → 325

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_006242427.4 → XP_006242489.1 poly(rC)-binding protein 2 isoform X33

See identical proteins and their annotated locations for XP_006242489.1

UniProtKB/TrEMBL

A0A0G2KBC5

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:237 → 312

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063264000.1 → XP_063120070.1 poly(rC)-binding protein 2 isoform X35
XM_006242418.4 → XP_006242480.1 poly(rC)-binding protein 2 isoform X20

See identical proteins and their annotated locations for XP_006242480.1

UniProtKB/TrEMBL

A0A0G2KBC5, A0A8I5ZS12, Q6AYU2

Related

ENSRNOP00000081612.1, ENSRNOT00000111669.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263975.1 → XP_063120045.1 poly(rC)-binding protein 2 isoform X12
XM_063263976.1 → XP_063120046.1 poly(rC)-binding protein 2 isoform X13
XM_063263980.1 → XP_063120050.1 poly(rC)-binding protein 2 isoform X17
XM_063263963.1 → XP_063120033.1 poly(rC)-binding protein 2 isoform X1
XM_063263962.1 → XP_063120032.1 poly(rC)-binding protein 2 isoform X1
XM_063263965.1 → XP_063120035.1 poly(rC)-binding protein 2 isoform X2
XM_063263974.1 → XP_063120044.1 poly(rC)-binding protein 2 isoform X11
XM_063263969.1 → XP_063120039.1 poly(rC)-binding protein 2 isoform X6
XM_006242422.4 → XP_006242484.1 poly(rC)-binding protein 2 isoform X24

See identical proteins and their annotated locations for XP_006242484.1

UniProtKB/TrEMBL

A0A0G2KBC5, A0A8I6AGT9, A6KCV8

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:268 → 343

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263989.1 → XP_063120059.1 poly(rC)-binding protein 2 isoform X25
XM_063264003.1 → XP_063120073.1 poly(rC)-binding protein 2 isoform X36
XM_063263966.1 → XP_063120036.1 poly(rC)-binding protein 2 isoform X4
XM_063263970.1 → XP_063120040.1 poly(rC)-binding protein 2 isoform X7

Related

ENSRNOP00000085087.2, ENSRNOT00000105769.2
XM_017595014.3 → XP_017450503.1 poly(rC)-binding protein 2 isoform X15

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:236 → 311

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263979.1 → XP_063120049.1 poly(rC)-binding protein 2 isoform X16
XM_063263973.1 → XP_063120043.1 poly(rC)-binding protein 2 isoform X10
XM_063263967.1 → XP_063120037.1 poly(rC)-binding protein 2 isoform X5
XM_063263983.1 → XP_063120053.1 poly(rC)-binding protein 2 isoform X21
XM_063263988.1 → XP_063120058.1 poly(rC)-binding protein 2 isoform X24

UniProtKB/TrEMBL

A0A8I6AGT9, A6KCV8
XM_063263990.1 → XP_063120060.1 poly(rC)-binding protein 2 isoform X26

Related

ENSRNOP00000093976.2, ENSRNOT00000109477.2
XM_063263995.1 → XP_063120065.1 poly(rC)-binding protein 2 isoform X30
XM_063263998.1 → XP_063120068.1 poly(rC)-binding protein 2 isoform X33
XM_063264001.1 → XP_063120071.1 poly(rC)-binding protein 2 isoform X35
XM_063263999.1 → XP_063120069.1 poly(rC)-binding protein 2 isoform X34

UniProtKB/TrEMBL

A6KCW0
XM_063264004.1 → XP_063120074.1 poly(rC)-binding protein 2 isoform X36
XM_017595007.3 → XP_017450496.1 poly(rC)-binding protein 2 isoform X3

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_063263981.1 → XP_063120051.1 poly(rC)-binding protein 2 isoform X18
XM_063263982.1 → XP_063120052.1 poly(rC)-binding protein 2 isoform X19

UniProtKB/TrEMBL

D4ACH3, Q6AYU5
XM_063263987.1 → XP_063120057.1 poly(rC)-binding protein 2 isoform X23
XM_063263991.1 → XP_063120061.1 poly(rC)-binding protein 2 isoform X27

UniProtKB/TrEMBL

Q4V8F6
XM_063263992.1 → XP_063120062.1 poly(rC)-binding protein 2 isoform X28
XM_063263986.1 → XP_063120056.1 poly(rC)-binding protein 2 isoform X22
XM_063263996.1 → XP_063120066.1 poly(rC)-binding protein 2 isoform X31
XM_063263997.1 → XP_063120067.1 poly(rC)-binding protein 2 isoform X32
XM_063263964.1 → XP_063120034.1 poly(rC)-binding protein 2 isoform X1
XM_063263985.1 → XP_063120055.1 poly(rC)-binding protein 2 isoform X21

Related

ENSRNOP00000052173.4, ENSRNOT00000055302.5