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    stet stem cell tumor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    stetprovided by FlyBase
    Official Full Name
    stem cell tumorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020248
    Locus tag
    Dmel_CG33166
    See related
    AllianceGenome:FB:FBgn0020248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    B-Rho; brho; Brho; CG12083; CG12504; CG33166; Dmel\CG33166; rho-2; Rho-2; rho2; Rho2; Stet
    Summary
    Enables serine-type endopeptidase activity. Involved in epidermal growth factor receptor ligand maturation and male germ-line stem cell population maintenance. Located in Golgi membrane. Orthologous to human RHBDL1 (rhomboid like 1) and RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See stet in Genome Data Viewer
    Location:
    62A2-62A2; 3-0.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1475438..1489547, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1475438..1489547, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene ncRNA Neighboring gene rhomboid Neighboring gene N(alpha)-acetyltransferase 30 B Neighboring gene small non-coding RNA:CR43701 Neighboring gene robl62A Neighboring gene antisense RNA:CR45812 Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene uncharacterized protein Neighboring gene half pint

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alternative splice variants of rhomboid proteins: Comparative analysis of database entries for select model organisms and validation of functional potential. Powles J, et al. F1000Res, 2018. PMID 32201561, Free PMC Article
    2. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. Hudson AG, et al. PLoS One, 2013. PMID 23940622, Free PMC Article
    3. Developmental roles of Rhomboid proteases. Shilo BZ. Semin Cell Dev Biol, 2016 Dec. PMID 27423914
    4. Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. Parrott BB, et al. PLoS One, 2012. PMID 22586473, Free PMC Article
    5. Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Yamashita YM, et al. Cold Spring Harb Perspect Biol, 2010 Jan. PMID 20182603, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epidermal growth factor receptor ligand maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor ligand maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male germ-line stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stem cell tumor
    Names
    CG33166-PA
    CG33166-PB
    brother of rhomboid
    rhomboid-2
    rhomboid2
    stet-PA
    stet-PB
    NP_788450.1
    NP_788451.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1475438..1489547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176272.2 → NP_788450.1  stem cell tumor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788450.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P37, Q9W0E9
      Related
      FBpp0072596
      Conserved Domains (3) summary
      pfam01694
      Location:262 → 428
      Rhomboid; Rhomboid family
      pfam13499
      Location:91 → 156
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:75 → 115
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_176273.2 → NP_788451.1  stem cell tumor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0F1
      Related
      FBpp0072597
      Conserved Domains (1) summary
      pfam01694
      Location:107 → 273
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P37 Q86P37
    Q9BML4 Q9BML4
    Q9W0E9 Q9W0E9
    Q9W0F1 Q9W0F1

    Gene LinkOut

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