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    Alp10 Alkaline phosphatase 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alp10provided by FlyBase
    Official Full Name
    Alkaline phosphatase 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0035619
    Locus tag
    Dmel_CG10592
    See related
    AllianceGenome:FB:FBgn0035619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10592; Dmel\CG10592
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alp10 in Genome Data Viewer
    Location:
    64D5-64D5; 3-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5592741..5595272, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5585841..5588372, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene small non-coding RNA 357 Neighboring gene Msr-110 Neighboring gene lethal (3) persistent salivary gland 2 Neighboring gene spook Neighboring gene Alkaline phosphatase 9 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic analyses of Drosophila melanogaster models of chromatin modification disorders. MacPherson RA, et al. Genetics, 2023 Aug 9. PMID 37036413, Free PMC Article
    2. Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan. Yamashita K, et al. Dis Model Mech, 2021 Sep 1. PMID 34448472, Free PMC Article
    3. Two independent duplications forming the Cyp307a genes in Drosophila. Sztal T, et al. Insect Biochem Mol Biol, 2007 Oct. PMID 17785192
    4. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article
    5. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Xu C, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31852821, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase 10
    Names
    Alp10-PA
    CG10592-PA
    NP_647976.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5592741..5595272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139719.2 → NP_647976.1  alkaline phosphatase 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647976.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRM8
      Related
      FBpp0076835, FBtr0077129
      Conserved Domains (2) summary
      COG1785
      Location:56 → 510
      PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
      cl23718
      Location:75 → 511
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRM8 Q9VRM8

    Gene LinkOut

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