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    Best2 Bestrophin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Best2provided by FlyBase
    Official Full Name
    Bestrophin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035696
    Locus tag
    Dmel_CG10173
    See related
    AllianceGenome:FB:FBgn0035696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10173; dbest2; dBest2; Dmel\CG10173
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in peroxisome. Is expressed in several structures, including adult head; anterior endoderm anlage; embryonic hindgut; embryonic ventral epidermis; and epithelium. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to several human genes including BEST1 (bestrophin 1); BEST2 (bestrophin 2); and BEST3 (bestrophin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Best2 in Genome Data Viewer
    Location:
    65A10-65A10; 3-16 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6245933..6256665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6239033..6249765, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multi drug resistance 65 Neighboring gene uncharacterized protein Neighboring gene Lactate dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single Cl- channels activated by Ca2+ in Drosophila S2 cells are mediated by bestrophins. Chien LT, et al. J Gen Physiol, 2006 Sep. PMID 16940553, Free PMC Article
    2. Glial Chloride Channels in the Function of the Nervous System Across Species. Fernandez-Abascal J, et al. Adv Exp Med Biol, 2021. PMID 35138616, Free PMC Article
    3. Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Tavsanli BC, et al. Genesis, 2001 Nov. PMID 11747204
    4. Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. Chien LT, et al. J Gen Physiol, 2007 Nov. PMID 17968025, Free PMC Article
    5. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Hartzell HC, et al. Physiol Rev, 2008 Apr. PMID 18391176

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here it is reported that bestrophin2 is a component of native Calcium channel at the plasma membrane
      Title: Single Cl- channels activated by Ca2+ in Drosophila S2 cells are mediated by bestrophins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bestrophin 2
    Names
    Best2-PA
    CG10173-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6245933..6256665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168162.2 → NP_729159.2  bestrophin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729159.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU35, Q9VRW4
      Related
      FBpp0076718
      Conserved Domains (1) summary
      pfam01062
      Location:13 → 324
      Bestrophin; Bestrophin, RFP-TM, chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7YU35 Q7YU35
    Q9VRW4 Q9VRW4

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