SNA3 Sna3p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNA3
Official Full Name: Sna3p
Primary source: SGD:S000003687
Locus tag: YJL151C
See related: AllianceGenome:SGD:S000003687; FungiDB:YJL151C; VEuPathDB:YJL151C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ubiquitin protein ligase binding activity. Involved in endosome transport via multivesicular body sorting pathway and protein catabolic process. Located in fungal-type vacuole lumen. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SNA3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (136372..136773, complement)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

While the pattern of regulation of these two genes was similar, results showed that intermediate levels of inositol repressed INO1 and induced SNA3.
Title: Transcription regulation of a yeast gene from a downstream location.
Sna3 is a potential competitor of Bul1 for the Rsp5 WW domain affecting degradation of tryptophan permease Tat2.
Title: Overexpression of Sna3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1.
Sna3p undergoes Rsp5-dependent polyubiquitylation with K63-linked ubiquitin chains during its sorting to the endosomal pathway.
Title: Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation.
Sna3 circumvents Ub-mediated recognition by interacting directly with Rsp5, an E3 Ub ligase that catalyzes monoubiquitination of multivesicular bodies vesicle cargoes.
Title: Direct binding to Rsp5 mediates ubiquitin-independent sorting of Sna3 via the multivesicular body pathway.
These results uncover a series of determinants impacting Sna3 multivesicular bodies sorting, including unexpected roles for Rsp5.
Title: Characterization of multiple multivesicular body sorting determinants within Sna3: a role for the ubiquitin ligase Rsp5.
Sna3p sorting depends on a direct interaction between a PPAY motif within its C-terminal cytosolic tail and the WW domains of Rsp5p.
Title: Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endosome transport via multivesicular body sorting pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole lumen	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in vacuolar lumen	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sna3p

NP_012384.1

Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

136372..136773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181584.1 → NP_012384.1 TPA: Sna3p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012384.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW35, P14359, Q6B236

UniProtKB/TrEMBL

C7GPY1

Conserved Domains (1) summary

COG0401
Location:17 → 72

YqaE; Uncharacterized membrane protein YqaE, homolog of Blt101, UPF0057 family [Function unknown]