FUN26 nucleoside transmembrane transporter FUN26 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FUN26
Official Full Name: nucleoside transmembrane transporter FUN26
Primary source: SGD:S000000020
Locus tag: YAL022C
See related: AllianceGenome:SGD:S000000020; FungiDB:YAL022C; VEuPathDB:YAL022C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables nicotinamide riboside transmembrane transporter activity and nucleobase transmembrane transporter activity. Involved in nicotinamide riboside transport; nucleobase transport; and transmembrane transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to several human genes including SLC29A2 (solute carrier family 29 member 2) and SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FUN26 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (108877..110430, complement)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results demonstrate that FUN26 has a unique substrate transport profile relative to known ENT family members and that a purified ENT can be reconstituted in proteoliposomes for functional characterization in a defined system
Title: FUN26 (function unknown now 26) protein from saccharomyces cerevisiae is a broad selectivity, high affinity, nucleoside and nucleobase transporter.
Fun26, a homolog of human ENT (equilibrative nucleoside transporter), localizes to the vacuolar membrane and establishes the size of the vacuolar and cytosolic NmR pools
Title: Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables nicotinamide riboside transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide riboside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleobase transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nicotinamide riboside transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nucleoside transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nucleoside transmembrane transporter FUN26

NP_009380.1

High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

108877..110430 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178167.1 → NP_009380.1 TPA: nucleoside transmembrane transporter FUN26 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009380.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPJ6, P31381

UniProtKB/TrEMBL

A7A0E6, B3LUV6, B5VDK0, C7GPL3, N1P929

Conserved Domains (1) summary

TIGR00939
Location:81 → 514

2a57; Equilibrative Nucleoside Transporter (ENT)