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    VhaSFD Vacuolar H[+]-ATPase SFD subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34997, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VhaSFDprovided by FlyBase
    Official Full Name
    Vacuolar H[+]-ATPase SFD subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027779
    Locus tag
    Dmel_CG17332
    See related
    AllianceGenome:FB:FBgn0027779
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    144191_at; ATP6V1H; CG17332; Dmel\CG17332; v-ATPase; V-ATPase; V-type H+-ATPase; V1H; VA; vhaSFD
    Summary
    Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in determination of adult lifespan; dsRNA transport; and lysosomal lumen acidification. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including adult brain; embryonic/larval midgut primordium; female germline cell; gut section; and synaptic neuropil domain. Orthologous to human ATP6V1H (ATPase H+ transporting V1 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See VhaSFD in Genome Data Viewer
    Location:
    36A12-36A12; 2-52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16722883..16727826, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16722883..16727826, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cytochrome c distal Neighboring gene Cytochrome c proximal Neighboring gene mir-1006 stem loop Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene tRNA splicing endonuclease subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of V-ATPase in the regulation of cell size in the fly's visual system. Pyza E, et al. J Insect Physiol, 2004 Nov. PMID 15607501
    2. The roles of V-type H(+)-ATPase and Na(+)/K(+)-ATPase in energizing K(+) and H(+) transport in larval Drosophila gut epithelia. D'Silva NM, et al. J Insect Physiol, 2017 Apr. PMID 28188726
    3. Proteomic changes in response to crystal formation in Drosophila Malpighian tubules. Chung VY, et al. Fly (Austin), 2016 Apr 2. PMID 27064297, Free PMC Article
    4. A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila. Ren L, et al. PLoS One, 2018. PMID 30235233, Free PMC Article
    5. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Landis GN, et al. Genome Biol, 2003. PMID 12620118, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATPase activity, rotational mechanism IC
    Inferred by Curator
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of plasma membrane proton-transporting V-type ATPase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+]-ATPase SFD subunit
    Names
    CG17332-PA
    CG17332-PB
    CG17332-PD
    CG17332-PE
    V-ATPase H-subunit
    V-ATPase subunit H
    V-ATPase subunit V1H
    V1 H subunit
    VhaSFD-PA
    VhaSFD-PB
    VhaSFD-PD
    VhaSFD-PE
    vacuolar H+-ATPase SFD subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16722883..16727826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273581.1 → NP_001260510.1  vacuolar H[+]-ATPase SFD subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IP12, Q960C9, Q9V3J1, Q9VJJ2
      UniProtKB/TrEMBL
      M9PDK5
      Conserved Domains (2) summary
      COG5231
      Location:28 → 443
      VMA13; Vacuolar H+-ATPase V1 sector, subunit H [Energy production and conversion]
      cd00256
      Location:19 → 444
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    2. NM_165178.2 → NP_723993.1  vacuolar H[+]-ATPase SFD subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723993.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J1
      Related
      FBpp0080496
      Conserved Domains (2) summary
      COG5231
      Location:28 → 439
      VMA13; Vacuolar H+-ATPase V1 sector, subunit H [Energy production and conversion]
      cd00256
      Location:19 → 440
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    3. NM_078861.3 → NP_523585.2  vacuolar H[+]-ATPase SFD subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523585.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IP12, Q960C9, Q9V3J1, Q9VJJ2
      UniProtKB/TrEMBL
      M9PDK5
      Related
      FBpp0080494
      Conserved Domains (2) summary
      COG5231
      Location:28 → 443
      VMA13; Vacuolar H+-ATPase V1 sector, subunit H [Energy production and conversion]
      cd00256
      Location:19 → 444
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...

    4. NM_165177.2 → NP_723992.1  vacuolar H[+]-ATPase SFD subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723992.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J1
      Related
      FBpp0080495
      Conserved Domains (1) summary
      cd00256
      Location:19 → 518
      VATPase_H; VATPase_H, regulatory vacuolar ATP synthase subunit H (Vma13p); activation component of the peripheral V1 complex of V-ATPase, a heteromultimeric enzyme which uses ATP to actively transport protons into organelles and extracellular compartments. The ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDK5 M9PDK5
    Q9V3J1.2 Q9V3J1

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