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    MRP4 mitochondrial 37S ribosomal protein MRP4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MRP4
    Official Full Name
    mitochondrial 37S ribosomal protein MRP4
    Primary source
    SGD:S000000996
    Locus tag
    YHL004W
    See related
    AllianceGenome:SGD:S000000996; FungiDB:YHL004W; VEuPathDB:YHL004W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    uS2m
    Summary
    A structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Part of mitochondrial small ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 36. Orthologous to human MRPS2 (mitochondrial ribosomal protein S2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MRP4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (99219..100403)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase kinase STE20 Neighboring gene Shu1p Neighboring gene uncharacterized protein Neighboring gene sphingosine N-acyltransferase LAG1 Neighboring gene ESCRT-0 subunit protein HSE1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a yeast mitochondrial ribosomal protein structurally related to the mammalian 68-kDa high affinity laminin receptor. Davis SC, et al. J Biol Chem, 1992 Mar 15. PMID 1531984
    2. Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues. Saveanu C, et al. J Biol Chem, 2001 May 11. PMID 11278769
    3. Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components. Gan X, et al. Eur J Biochem, 2002 Nov. PMID 12392552
    4. Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. Frazier AE, et al. J Cell Biol, 2006 Feb 13. PMID 16476776, Free PMC Article
    5. MitoStores: chaperone-controlled protein granules store mitochondrial precursors in the cytosol. Krämer L, et al. EMBO J, 2023 Apr 3. PMID 36704946, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 37S ribosomal protein MRP4
    NP_011859.1
    • Mitochondrial ribosomal protein of the small subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      99219..100403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179084.1 → NP_011859.1  TPA: mitochondrial 37S ribosomal protein MRP4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKR0, P32902
      UniProtKB/TrEMBL
      A6ZSP8, B3LSB4, B5VJS4, C7GX98, C8ZA61, G2WF62, N1P348
      Conserved Domains (1) summary
      pfam00318
      Location:188 → 383
      Ribosomal_S2; Ribosomal protein S2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32902.1

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