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    IRC5 putative ATPase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IRC5
    Official Full Name
    putative ATPase
    Primary source
    SGD:S000001934
    Locus tag
    YFR038W
    See related
    AllianceGenome:SGD:S000001934; FungiDB:YFR038W; VEuPathDB:YFR038W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; chromatin binding activity; and nucleosome array spacer activity. Involved in mitotic recombination. Acts upstream of or within error-free translesion synthesis. Located in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IRC5 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (229380..231941)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit CDC26 Neighboring gene Rsc8p Neighboring gene Osw7p Neighboring gene Sap155p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Replication-independent assembly of nucleosome arrays in a novel yeast chromatin reconstitution system involves antisilencing factor Asf1p and chromodomain protein Chd1p. Robinson KM, et al. Mol Cell Biol, 2003 Nov. PMID 14585955, Free PMC Article
    2. Error-free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin. Litwin I, et al. EMBO J, 2018 Sep 14. PMID 30111537, Free PMC Article
    3. The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks. Shim EY, et al. Mol Cell Biol, 2005 May. PMID 15870268, Free PMC Article
    4. The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast. Litwin I, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28383696, Free PMC Article
    5. Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Shiratori A, et al. Yeast, 1999 Feb. PMID 10077188

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Irc5 is an auxiliary factor that is involved in cohesin association with chromatin in yeast.
      Title: The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within error-free translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATPase
    NP_116696.2
    • Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      229380..231941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180003.1 → NP_116696.2  TPA: putative ATPase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116696.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTS1, P43610
      UniProtKB/TrEMBL
      G2WDH9
      Conserved Domains (3) summary
      cd00046
      Location:242 → 383
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:225 → 542
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:602 → 717
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43610.2

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