OTU1 ubiquitin-specific protease OTU1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: OTU1
Official Full Name: ubiquitin-specific protease OTU1
Primary source: SGD:S000001850
Locus tag: YFL044C
See related: AllianceGenome:SGD:S000001850; FungiDB:YFL044C; VEuPathDB:YFL044C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Orthologous to human YOD1 (YOD1 deubiquitinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See OTU1 in Genome Data Viewer

Location:: chromosome: VI

Exon count:: 1

Sequence:: Chromosome: VI; NC_001138.5 (44655..45560, complement)

Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001138.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that 39GYPP42 (S3/S4) loop of yeast OTU1 is critical for interaction with human p97/valosin-containing protein (VCP).
Title: Structural basis for ovarian tumor domain-containing protein 1 (OTU1) binding to p97/valosin-containing protein (VCP).

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin-specific protease OTU1

NP_116610.1

EC 3.4.19.12

Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001138.5 Reference assembly

Range

44655..45560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179923.1 → NP_116610.1 TPA: ubiquitin-specific protease OTU1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116610.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTI6, P43558

UniProtKB/TrEMBL

A7A1Z5, B3LUG7, B5VHY3, C8Z7N8, N1P319

Conserved Domains (1) summary

COG5539
Location:1 → 300

COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]