TSC11 TORC2 complex subunit TSC11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TSC11
Official Full Name: TORC2 complex subunit TSC11
Primary source: SGD:S000000895
Locus tag: YER093C
See related: AllianceGenome:SGD:S000000895; FungiDB:YER093C; VEuPathDB:YER093C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AVO3
Summary: Enables protein-membrane adaptor activity. Involved in several processes, including establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization; and protein localization to plasma membrane. Located in cytosol. Part of TORC2 complex. Is active in plasma membrane. Human ortholog(s) of this gene implicated in breast ductal carcinoma; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TSC11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (343320..347612, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
Title: Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
Moreover, hyperosmotic conditions block TORC2-dependent Ypk1-mediated Fps1 phosphorylation, causing channel closure, glycerol accumulation, and enhanced survival under hyperosmotic stress.
Title: Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.
Avo3p is a structural and signaling scaffold for TORC2.
Title: Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling.
the function of TSC11 in the regulation of cell integrity
Title: Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-membrane adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IPI Inferred from Physical Interaction more info	PubMed
involved_in fungal-type cell wall organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IPI Inferred from Physical Interaction more info	PubMed
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosol	HDA more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TORC2 complex subunit TSC11

NP_011018.1

Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

343320..347612 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178984.1 → NP_011018.1 TPA: TORC2 complex subunit TSC11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011018.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM00, P40061

UniProtKB/TrEMBL

B3LRL1, C7GRS6

Conserved Domains (5) summary

PRK08581
Location:23 → 323

PRK08581; amidase domain-containing protein

pfam14663
Location:977 → 1080

RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain

pfam14664
Location:326 → 669

RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term

pfam14666
Location:853 → 957

RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain

pfam14668
Location:1147 → 1217

RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5