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    EDC2 Edc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EDC2
    Official Full Name
    Edc2p
    Primary source
    SGD:S000000837
    Locus tag
    YER035W
    See related
    AllianceGenome:SGD:S000000837; FungiDB:YER035W; VEuPathDB:YER035W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in deadenylation-dependent decapping of nuclear-transcribed mRNA and positive regulation of translation in response to stress. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EDC2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (222639..223076)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Zrg8p Neighboring gene uncharacterized protein Neighboring gene ATP-binding cassette family ATPase ARB1 Neighboring gene bifunctional nucleotidase/lysophosphatidic acid phosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme. Schwartz D, et al. RNA, 2003 Feb. PMID 12554867, Free PMC Article
    2. Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae. Neef DW, et al. Mol Microbiol, 2009 Sep. PMID 19682251, Free PMC Article
    3. Analysis of recombinant yeast decapping enzyme. Steiger M, et al. RNA, 2003 Feb. PMID 12554866, Free PMC Article
    4. Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition. Borja MS, et al. RNA, 2011 Feb. PMID 21148770, Free PMC Article
    5. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Dunckley T, et al. Genetics, 2001 Jan. PMID 11139489, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this report the authors show that strains lacking Edc2, as well as the paralogous protein Edc1, are compromised for growth under persistent heat stress.
      Title: Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Edc2p
    NP_010952.3
    • RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      222639..223076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178926.3 → NP_010952.3  TPA: Edc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010952.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT4, P40023
      UniProtKB/TrEMBL
      A6ZQY4, B3LS47, C7GSI2, C8Z737, G2WCR8, N1P6V7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40023.1

    Gene LinkOut

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