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    ARH1 NADPH-adrenodoxin reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARH1
    Official Full Name
    NADPH-adrenodoxin reductase
    Primary source
    SGD:S000002784
    Locus tag
    YDR376W
    See related
    AllianceGenome:SGD:S000002784; FungiDB:YDR376W; VEuPathDB:YDR376W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NADPH-adrenodoxin reductase activity. Involved in intracellular iron ion homeostasis and ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Used to study Parkinson's disease; auditory system disease; optic atrophy; and retinitis pigmentosa. Orthologous to human FDXR (ferredoxin reductase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARH1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1226822..1228303)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Wip1p Neighboring gene bifunctional AAA family ATPase chaperone/translocase BCS1 Neighboring gene F1F0 ATP synthase subunit f Neighboring gene U4/U6-U5 snRNP complex subunit LSM6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of recombinant adrenodoxin reductase homologue (Arh1p) from yeast. Implication in in vitro cytochrome p45011beta monooxygenase system. Lacour T, et al. J Biol Chem, 1998 Sep 11. PMID 9727014
    2. ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Manzella L, et al. Yeast, 1998 Jun 30. PMID 9818721
    3. Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis. Li J, et al. J Biol Chem, 2001 Jan 12. PMID 11035018
    4. 11 beta-hydroxylase activity in recombinant yeast mitochondria. In vivo conversion of 11-deoxycortisol to hydrocortisone. Dumas B, et al. Eur J Biochem, 1996 Jun 1. PMID 8681964
    5. Predictive reconstruction of the mitochondrial iron-sulfur cluster assembly metabolism: I. The role of the protein pair ferredoxin-ferredoxin reductase (Yah1-Arh1). Alves R, et al. Proteins, 2004 Aug 1. PMID 15211518

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NADPH-adrenodoxin reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADPH-adrenodoxin reductase
    NP_010664.3
    • Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1226822..1228303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180684.3 → NP_010664.3  TPA: NADPH-adrenodoxin reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010664.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT08, P32840, P48360
      UniProtKB/TrEMBL
      A6ZYX5, B3LFS6, C8Z5T9, G2WBB3, N1PAI9
      Conserved Domains (1) summary
      cl30539
      Location:18 → 486
      PLN02852; ferredoxin-NADP+ reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48360.1

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