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    TLD1 triglyceride-associated lipolysis regulator TLD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TLD1
    Official Full Name
    triglyceride-associated lipolysis regulator TLD1
    Primary source
    SGD:S000002683
    Locus tag
    YDR275W
    See related
    AllianceGenome:SGD:S000002683; FungiDB:YDR275W; VEuPathDB:YDR275W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BSC2
    Summary
    Acts upstream of or within cellular lipid catabolic process. Is active in lipid droplet. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TLD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1012252..1012959)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Don1p Neighboring gene uncharacterized protein Neighboring gene Pmp3p Neighboring gene Mth1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae. Kong Y, et al. Free Radic Res, 2020 Apr. PMID 32295440
    2. A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae. Samanfar B, et al. Mol Biosyst, 2014 Apr. PMID 24535059
    3. Tld1 is a regulator of triglyceride lipolysis that demarcates a lipid droplet subpopulation. Speer NO, et al. J Cell Biol, 2024 Jan 1. PMID 37889293, Free PMC Article
    4. Identification of stop codon readthrough genes in Saccharomyces cerevisiae. Namy O, et al. Nucleic Acids Res, 2003 May 1. PMID 12711673, Free PMC Article
    5. Genome-wide analysis of mRNAs targeted to yeast mitochondria. Marc P, et al. EMBO Rep, 2002 Feb. PMID 11818335, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae.
      Title: BSC2 induces multidrug resistance via contributing to the formation of biofilm in Saccharomyces cerevisiae.
    2. BSC2 deletion increased the rate of premature stop codon bypass. Bsc2p may function in negative regulation of premature stop codon bypass and hence regulate its own expression.
      Title: A global investigation of gene deletion strains that affect premature stop codon bypass in yeast, Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet HDA PubMed 
    is_active_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triglyceride-associated lipolysis regulator TLD1
    NP_010561.1
    • Protein that regulates lipolysis; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; TLD1 has a paralog, IRC23, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1012252..1012959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180583.1 → NP_010561.1  TPA: triglyceride-associated lipolysis regulator TLD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSQ6, Q05611
      UniProtKB/TrEMBL
      A6ZYM5, B3LG18, B5VGF6, C7GS93, C8Z5I8, G2WB15, N1PAG8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05611.1

    Gene LinkOut

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