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    SEC1 Sec1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC1
    Official Full Name
    Sec1p
    Primary source
    SGD:S000002571
    Locus tag
    YDR164C
    See related
    AllianceGenome:SGD:S000002571; FungiDB:YDR164C; VEuPathDB:YDR164C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNARE binding activity. Involved in positive regulation of vesicle fusion and vesicle docking involved in exocytosis. Located in cellular bud neck; cellular bud tip; and plasma membrane. Human ortholog(s) of this gene implicated in West syndrome; developmental and epileptic encephalopathy 4; and familial hemophagocytic lymphohistiocytosis 5. Orthologous to several human genes including STXBP2 (syntaxin binding protein 2) and STXBP3 (syntaxin binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (782041..784215, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Nbp2p Neighboring gene U2-type spliceosomal complex subunit CWC15 Neighboring gene Trm82p Neighboring gene exocyst subunit SEC5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae. Novick P, et al. Proc Natl Acad Sci U S A, 1979 Apr. PMID 377286, Free PMC Article
    2. Cloning and sequencing of the yeast Saccharomyces cerevisiae SEC1 gene localized on chromosome IV. Aalto MK, et al. Yeast, 1991 Aug-Sep. PMID 1767592
    3. Isolation of secretory vesicles from Saccharomyces cerevisiae. Holcomb CL, et al. Anal Biochem, 1987 Nov 1. PMID 3324821
    4. Engineering of vesicle trafficking improves heterologous protein secretion in Saccharomyces cerevisiae. Hou J, et al. Metab Eng, 2012 Mar. PMID 22265825
    5. Molecular characterization of the SEC1 gene of Saccharomyces cerevisiae: subcellular distribution of a protein required for yeast protein secretion. Egerton M, et al. Yeast, 1993 Jul. PMID 8368004

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hsp110 (Sse1 and Sse2) associates with the 19S regulatory particle of the 26S proteasome and interacts with Hsp70 (Ssa1, Ssa2) to facilitate the delivery of Hsp70 substrates for proteasomal degradation.
      Title: Hsp70-Hsp110 chaperones deliver ubiquitin-dependent and -independent substrates to the 26S proteasome for proteolysis in yeast.
    2. upon vesicle arrival, Sec6 is proposed to release Sec9 in favor of Sec6-exocyst assembly and to simultaneously recruit Sec1 to sites of secretion for coordinated SNARE complex formation and membrane fusion.
      Title: Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1.
    3. Data show that yeast Sec1p is required before and after SNARE complex assembly, in support of general requirements for Sec1/Munc18 proteins in both vesicle docking and fusion.
      Title: Yeast Sec1p functions before and after vesicle docking.
    4. Data show that Sec1p binds specifically to the ternary SNARE complex, with no detectable binding to the binary t-SNARE complex or any of the three individual SNAREs in their uncomplexed forms.
      Title: Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p.
    5. Our results suggest that Sec1p couples exocyst-mediated vesicle tethering with SNARE-mediated docking and fusion.
      Title: Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p.
    6. Sec1p directly stimulates SNARE-mediated membrane fusion
      Title: Sec1p directly stimulates SNARE-mediated membrane fusion in vitro.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNARE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking involved in exocytosis IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sec1p
    NP_010448.1
    • Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      782041..784215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180471.1 → NP_010448.1  TPA: Sec1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSE4, P30619
      UniProtKB/TrEMBL
      A6ZYC2, B3LGC0, C7GQF5, C8Z578, G2WAR2
      Conserved Domains (1) summary
      COG5158
      Location:1 → 644
      SEC1; Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30619.1

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