SSS1 translocon subunit SSS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SSS1
Official Full Name: translocon subunit SSS1
Primary source: SGD:S000002493
Locus tag: YDR086C
See related: AllianceGenome:SGD:S000002493; FungiDB:YDR086C; VEuPathDB:YDR086C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein transmembrane transporter activity and structural molecule activity. Contributes to protein-transporting ATPase activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Located in nuclear inner membrane. Part of Sec61 translocon complex and Ssh1 translocon complex. Used to study cancer. Orthologous to human SEC61G (SEC61 translocon subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SSS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (616928..617170, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cancer associated mutations in Sec61gamma alter the permeability of the ER translocase.
Title: Cancer associated mutations in Sec61γ alter the permeability of the ER translocase.
The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.
Title: The conserved C-terminus of Sss1p is required to maintain the endoplasmic reticulum permeability barrier.
The specific sequence of the hydrophobic core of the Sss1p tail anchor is critical for stabilizing the Sec61 complex and, therefore, Sec complexes.
Title: Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence.
Data reveal that the cytosolic domain of Ss1p is required for Sec61p interaction but that the transmembrane clamp domain is required to complete activation of the translocon after precursor targeting to Sec61p.
Title: Sss1p is required to complete protein translocon activation.
Sbh1p co-precipitates with the ER transmembrane protein Rtn1p. Sbh1p-Rtn1p complexes do not appear to contain Sss1p and Sec61p.
Title: The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to protein-transporting ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IGI Inferred from Genetic Interaction more info	PubMed
enables structural molecule activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in post-translational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in post-translational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IDA Inferred from Direct Assay more info	PubMed
part_of Ssh1 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ssh1 translocon complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translocon subunit SSS1

NP_010371.1

Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

616928..617170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180394.1 → NP_010371.1 TPA: translocon subunit SSS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010371.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS73, P35179

UniProtKB/TrEMBL

A6ZY52, B3LGI5, C7GVQ0, C8Z504, G2WAJ1, N1P854

Conserved Domains (1) summary

COG2443
Location:15 → 79

Sss1; Preprotein translocase subunit Sss1 [Intracellular trafficking, secretion, and vesicular transport]