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    DTD1 D-tyrosyl-tRNA(Tyr) deacylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DTD1
    Official Full Name
    D-tyrosyl-tRNA(Tyr) deacylase
    Primary source
    SGD:S000002378
    Locus tag
    YDL219W
    See related
    AllianceGenome:SGD:S000002378; FungiDB:YDL219W; VEuPathDB:YDL219W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-leucyl-tRNA(Leu) deacylase activity and D-tyrosyl-tRNA(Tyr) deacylase activity. Involved in D-leucine catabolic process; D-tyrosine catabolic process; and tRNA metabolic process. Located in cytoplasm. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DTD1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (65242..65765)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Fmp45p Neighboring gene telomere-binding protein CDC13 Neighboring gene uncharacterized protein Neighboring gene translocation channel protein TIM22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. D-tyrosyl-tRNA(Tyr) metabolism in Saccharomyces cerevisiae. Soutourina J, et al. J Biol Chem, 2000 Apr 21. PMID 10766779
    2. Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression. Benko AL, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618371, Free PMC Article
    3. Metabolism of D-aminoacyl-tRNAs in Escherichia coli and Saccharomyces cerevisiae cells. Soutourina J, et al. J Biol Chem, 2000 Oct 20. PMID 10918062
    4. Lithium chloride sensitivity connects the activity of PEX11 and RIM20 to the translation of PGM2 and other mRNAs with structured 5'-UTRs. Jagadeesan SK, et al. Mol Cell Biochem, 2022 Nov. PMID 35598219
    5. DBP7 and YRF1-6 Are Involved in Cell Sensitivity to LiCl by Regulating the Translation of PGM2 mRNA. Jagadeesan SK, et al. Int J Mol Sci, 2023 Jan 16. PMID 36675300, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-aminoacyl-tRNA deacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-leucyl-tRNA(Leu) deacylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-leucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-tyrosine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-tyrosyl-tRNA(Tyr) deacylase
    NP_010062.1
    • D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      65242..65765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180279.1 → NP_010062.1  TPA: D-tyrosyl-tRNA(Tyr) deacylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010062.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRD5, Q07648
      UniProtKB/TrEMBL
      A6ZXB4, B3LH99, C7GSV8, C8Z6Q0, G2WBU8, N1P4G9
      Conserved Domains (1) summary
      cl00253
      Location:1 → 148
      Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07648.1

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