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    TRX3 Trx3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRX3
    Official Full Name
    Trx3p
    Primary source
    SGD:S000000679
    Locus tag
    YCR083W
    See related
    AllianceGenome:SGD:S000000679; FungiDB:YCR083W; VEuPathDB:YCR083W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables disulfide oxidoreductase activity. Involved in cellular response to oxidative stress. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRX3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (259578..259961)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Srb8p Neighboring gene Ahc2p Neighboring gene chromatin-silencing transcriptional regulator TUP1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial Prx1 functions as a redox signaling molecule that oxidizes Trx3 and promotes apoptosis.
      Title: Oxidation of the yeast mitochondrial thioredoxin promotes cell death.
    2. crystal structures of yeast Trx3 in oxidized and reduced forms at 1.80 & 2.10 A, respectively; findings providesome new insights into the putative function of the additional cysteine residues of Trx3
      Title: Structural and mechanistic analyses of yeast mitochondrial thioredoxin Trx3 reveal putative function of its additional cysteine residues.
    3. S. cerevisiae Trx3 was overexpressed in Escherichia coli was purified and crystallized and xray diffraction performed.
      Title: Expression, purification, crystallization and preliminary X-ray diffraction analysis of mitochondrial thioredoxin Trx3 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Trx3p
    NP_010006.1
    • Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      259578..259961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178789.1 → NP_010006.1  TPA: Trx3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010006.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR84, P25372
      UniProtKB/TrEMBL
      A6ZTQ5, B3LUD7, C7GUW5, C8Z4H0, G2WA91, N1P7Q3
      Conserved Domains (1) summary
      cd02947
      Location:35 → 125
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25372.1

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