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    Spn77Bc Serpin 77Bc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn77Bcprovided by FlyBase
    Official Full Name
    Serpin 77Bcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036970
    Locus tag
    Dmel_CG6289
    See related
    AllianceGenome:FB:FBgn0036970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6289; Dmel\CG6289; FBgn0036970; Spn77
    Summary
    Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; adult hemolymph; female reproductive system; sperm storage organ; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Henoch-Schoenlein purpura; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen); HMSD (histocompatibility minor serpin domain containing); and SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Spn77Bc in Genome Data Viewer
    Location:
    77B4-77B4; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20342634..20344319)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20335734..20337419)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Serpin 77Bb Neighboring gene pseudo Neighboring gene pseudo Neighboring gene Retinoblastoma binding protein 5 Neighboring gene eukaryotic translation release factor 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Targeted gene deletion and phenotypic analysis of the Drosophila melanogaster seminal fluid protease inhibitor Acp62F. Mueller JL, et al. Genetics, 2008 Mar. PMID 18245332, Free PMC Article
    2. Serpins in arthropod biology. Meekins DA, et al. Semin Cell Dev Biol, 2017 Feb. PMID 27603121, Free PMC Article
    3. Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster. Ravi Ram K, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17116868, Free PMC Article
    4. Fates and targets of male accessory gland proteins in mated female Drosophila melanogaster. Ravi Ram K, et al. Insect Biochem Mol Biol, 2005 Sep. PMID 15979005
    5. New genes in Drosophila quickly become essential. Chen S, et al. Science, 2010 Dec 17. PMID 21164016, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    NOT enables serine-type endopeptidase inhibitor activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 77Bc
    Names
    CG6289-PA
    CG6289-PB
    Spn77Bc-PA
    Spn77Bc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20342634..20344319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140950.2 → NP_649207.1  serpin 77Bc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQZ7, Q9VPH9
      Related
      FBpp0077830
      Conserved Domains (1) summary
      cd00172
      Location:36 → 410
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_001275174.1 → NP_001262103.1  serpin 77Bc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQZ7, Q9VPH9
      Conserved Domains (1) summary
      cd00172
      Location:36 → 410
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPH9 Q9VPH9

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