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    ILS1 isoleucine--tRNA ligase ILS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852202, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ILS1
    Official Full Name
    isoleucine--tRNA ligase ILS1
    Primary source
    SGD:S000000172
    Locus tag
    YBL076C
    See related
    AllianceGenome:SGD:S000000172; FungiDB:YBL076C; VEuPathDB:YBL076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables isoleucine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in isoleucyl-tRNA aminoacylation. Located in cytosol. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ILS1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (81043..84261, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Nup170p Neighboring gene ubiquitin-like protein ATG8 Neighboring gene Hsp70 family ATPase SSA3 Neighboring gene U5 snRNP complex subunit AAR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoleucyl-tRNA synthetase from baker's yeast: the 3'-hydroxyl group of the 3'-terminal ribose is essential for preventing misacylation of tRNAIle-C-C-A with misactivated valine. von der Haar F, et al. FEBS Lett, 1975 Aug 15. PMID 1098931
    2. Expression and characterization of a recombinant yeast isoleucyl-tRNA synthetase. Racher KI, et al. J Biol Chem, 1991 Sep 15. PMID 1910039
    3. Isolation and complete sequence of the yeast isoleucyl-tRNA synthetase gene (ILS1). Martindale DW, et al. Curr Genet, 1989 Feb. PMID 2663194
    4. Structure of the yeast isoleucyl-tRNA synthetase gene (ILS1). DNA-sequence, amino-acid sequence of proteolytic peptides of the enzyme and comparison of the structure to those of other known aminoacyl-tRNA synthetases. Englisch U, et al. Biol Chem Hoppe Seyler, 1987 Aug. PMID 3311074
    5. Aminoacyl-tRNA synthetase complex in Saccharomyces cerevisiae. Harris CL, et al. Biochem J, 1995 Jul 1. PMID 7619074, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isoleucine--tRNA ligase ILS1
    NP_009477.1
    • Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      81043..84261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178316.1 → NP_009477.1  TPA: isoleucine--tRNA ligase ILS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPS6, P09436
      UniProtKB/TrEMBL
      A6ZKM5, B3LNK9, B5VDR4, C7GK57, G2W8T5, N1PAU7
      Conserved Domains (1) summary
      PLN02882
      Location:8 → 1037
      PLN02882; aminoacyl-tRNA ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09436.1

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