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    OPT2 Opt2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856324, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OPT2
    Official Full Name
    Opt2p
    Primary source
    SGD:S000006398
    Locus tag
    YPR194C
    See related
    AllianceGenome:SGD:S000006398; FungiDB:YPR194C; VEuPathDB:YPR194C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oligopeptide transmembrane transporter activity. Involved in several processes, including cell redox homeostasis; positive regulation of monopolar cell growth; and vacuole fusion, non-autophagic. Located in Golgi trans cisterna; peroxisome; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OPT2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (924304..926937, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aqy1p Neighboring gene histone acetyltransferase Neighboring gene uncharacterized protein Neighboring gene putative maltose-responsive transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry. Yamauchi S, et al. J Cell Sci, 2015 Jan 1. PMID 25359886
    2. Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Yu D, et al. Bioinformatics, 2011 Aug 15. PMID 21685046, Free PMC Article
    3. Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. Bourbouloux A, et al. J Biol Chem, 2000 May 5. PMID 10788431
    4. Nutrient regulation of oligopeptide transport in Saccharomyces cerevisiae. Wiles AM, et al. Microbiology (Reading), 2006 Oct. PMID 17005992
    5. Novel role for the Saccharomyces cerevisiae oligopeptide transporter Opt2 in drug detoxification. Aouida M, et al. Biochem Cell Biol, 2009 Aug. PMID 19767828

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that Opt2 is a novel factor involved in cell homeostasis by regulating lipid asymmetry.
      Title: Opt2 mediates the exposure of phospholipids during cellular adaptation to altered lipid asymmetry.
    2. Authors show that budding yeast Opt2, a close homolog of the plasma membrane glutathione transporter Opt1, localizes to peroxisomes.
      Title: The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oligopeptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oligopeptide transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oligopeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oligopeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligopeptide transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of monopolar cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of vacuole organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Opt2p
    NP_015520.1
    • Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      924304..926937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184291.1 → NP_015520.1  TPA: Opt2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4J4, Q06593
      UniProtKB/TrEMBL
      A6ZX68, N1P2J1
      Conserved Domains (1) summary
      cl14607
      Location:141 → 839
      OPT; OPT oligopeptide transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06593.1

    Gene LinkOut

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