YOP1 Yop1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YOP1
Official Full Name: Yop1p
Primary source: SGD:S000006232
Locus tag: YPR028W
See related: AllianceGenome:SGD:S000006232; FungiDB:YPR028W; VEuPathDB:YPR028W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YIP2
Summary: Involved in several processes, including ER-dependent peroxisome organization; endoplasmic reticulum organization; and nuclear pore complex assembly. Located in endoplasmic reticulum tubular network and membrane. Used to study hereditary spastic paraplegia 31. Human ortholog(s) of this gene implicated in retinitis pigmentosa 77. Orthologous to several human genes including REEP5 (receptor accessory protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YOP1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 2

Sequence:: Chromosome: XVI; NC_001148.4 (623527..624202)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reconstitution of a dynamic tubular membrane network with purified endoplasmic reticulum proteins; proteoliposomes containing the membrane-fusing GTPase Sey1p and the curvature-stabilizing protein Yop1p from Saccharomyces cerevisiae can form a tubular network upon addition of GTP
Title: Reconstitution of the tubular endoplasmic reticulum network with purified components.
two integral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex29 and Pex30, reside in distinct regions of the ER and associate with Rtn1 and Yop1, reticulon family members that contribute to ER morphology, to govern peroxisome emergence from the ER.
Title: Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.
Rtn1 and Yop1 also physically interacted with Ndc1 and other NPC membrane proteins. We propose that NPC and SPB biogenesis are altered in cells lacking Rtn1 and Yop1 due to competition between these complexes for Ndc1
Title: Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1.
Studies suggest that op1 protein could function as phospholipid-GlcCer flippases.
Title: Reconstitution of glucosylceramide flip-flop across endoplasmic reticulum: implications for mechanism of glycosphingolipid biosynthesis.
reveal and dissect the critical roles of the reticulon homology domain proteins (Rtn1p, Rtn2p, and Yop1p) in brome mosaic virus RNA replication compartment formation and function
Title: Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function.
In this study, we report that members of the RTN and Yop1/DP1 families are required for nuclear pore formation.
Title: ER membrane-bending proteins are necessary for de novo nuclear pore formation.
when purified Yop1p was incorporated into proteoliposomes, narrow tubules were generated; tubule formation occurred with different lipids and required essentially only the central portion of the protein including its two long hydrophobic segments
Title: Membrane proteins of the endoplasmic reticulum induce high-curvature tubules.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear pore complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cell periphery	HDA more info	PubMed
located_in cellular bud	HDA more info	PubMed
located_in cellular bud tip	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Yop1p

NP_015353.1

Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

623527..624202

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184125.1 → NP_015353.1 TPA: Yop1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015353.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W438, Q12402

UniProtKB/TrEMBL

A6ZWS1, B3LL89, C7GQB0, C8ZJ52, G2WPK6, N1NXH4

Conserved Domains (1) summary

COG5052
Location:1 → 180

YOP1; Protein involved in membrane traffic [Intracellular trafficking and secretion]