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    OAZ1 Oaz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OAZ1
    Official Full Name
    Oaz1p
    Primary source
    SGD:S000005973
    Locus tag
    YPL052W
    See related
    AllianceGenome:SGD:S000005973; FungiDB:YPL052W; VEuPathDB:YPL052W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YPL052W-A
    Summary
    Enables ornithine decarboxylase inhibitor activity. Involved in negative regulation of translational frameshifting and regulation of proteasomal protein catabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OAZ1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (458799..459678)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Lee1p Neighboring gene putative mannosyltransferase Neighboring gene Arf family GTPase ARL3 Neighboring gene mannosyltransferase complex subunit MNN9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. Palanimurugan R, et al. EMBO J, 2004 Dec 8. PMID 15538383, Free PMC Article
    2. Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Kurian L, et al. Nature, 2011 Sep 7. PMID 21900894
    3. Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae. Halwas K, et al. Int J Mol Sci, 2022 Oct 26. PMID 36361762, Free PMC Article
    4. Epigenetic control of polyamines by the prion [PSI+]. Namy O, et al. Nat Cell Biol, 2008 Sep. PMID 19160487
    5. Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex. Chattopadhyay MK, et al. Biochem Biophys Res Commun, 2011 Mar 11. PMID 21295540, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae.
      Title: Hypusinated eIF5A Promotes Ribosomal Frameshifting during Decoding of ODC Antizyme mRNA in Saccharomyces cerevisiae.
    2. The molecular weight of the ODC:AZ complex is 90 kDa, which indicates a one to one stoichiometric binding of AZ and ODC in vitro.
      Title: Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex.
    3. Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme
      Title: Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme.
    4. Data suggest that polyamines inhibit their ornithine decarboxylase-mediated biosynthesis by two mechanisms, the control of Oaz1 synthesis and inhibition of its degradation.
      Title: Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of translational frameshifting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Oaz1p
    NP_015273.2
    • Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      458799..459678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183866.4 → NP_015273.2  TPA: Oaz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015273.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W2, Q02803
      UniProtKB/TrEMBL
      G2WPC6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02803.2

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