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    GDH1 glutamate dehydrogenase (NADP(+)) GDH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854557, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GDH1
    Official Full Name
    glutamate dehydrogenase (NADP(+)) GDH1
    Primary source
    SGD:S000005902
    Locus tag
    YOR375C
    See related
    AllianceGenome:SGD:S000005902; FungiDB:YOR375C; VEuPathDB:YOR375C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DHE4; URE1
    Summary
    Enables glutamate dehydrogenase (NADP+) activity. Involved in glutamate biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; and hypoglycemia. Orthologous to human GLUD1 (glutamate dehydrogenase 1) and GLUD2 (glutamate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GDH1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1041678..1043042, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Nud1p Neighboring gene aldehyde dehydrogenase (NADP(+)) ALD4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Saccharomyces cerevisiae nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase by proteolysis during carbon starvation. Mazón MJ, et al. J Bacteriol, 1979 Aug. PMID 37242, Free PMC Article
    2. Ammonia assimilation in S. cerevisiae under chemostatic growth. Lacerda V, et al. Appl Biochem Biotechnol, 1992 Jan-Mar. PMID 1329653
    3. Cloning, sequencing and expression of the Schwanniomyces occidentalis NADP-dependent glutamate dehydrogenase gene. De Zoysa PA, et al. Curr Genet, 1991 Aug. PMID 1934128
    4. Nucleotide sequence of the GDH gene coding for the NADP-specific glutamate dehydrogenase of Saccharomyces cerevisiae. Nagasu T, et al. Gene, 1985. PMID 2932370
    5. Nucleotide sequence of yeast GDH1 encoding nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase. Moye WS, et al. J Biol Chem, 1985 Jul 15. PMID 2989290

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucose starvation triggered the transition of the soluble form of Gdh1 into the insoluble aggregate form.
      Title: The NADP(+)-dependent glutamate dehydrogenase Gdh1 is subjected to glucose starvation-induced reversible aggregation that affects stress resistance in yeast.
    2. The role of glutamate dehydrogenase 1 (Gdh1) in the regulation of telomeric silencing.
      Title: Functions for diverse metabolic activities in heterochromatin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glutamate dehydrogenase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate dehydrogenase (NADP+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glutamate dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate dehydrogenase (NADP(+)) GDH1
    NP_015020.3
    • NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1041678..1043042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183795.3 → NP_015020.3  TPA: glutamate dehydrogenase (NADP(+)) GDH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015020.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W368, P07262, Q08899
      UniProtKB/TrEMBL
      A6ZPK3, B3LK29, C7GUL4, C8ZHC3, G2WNN5, N1NX34
      Conserved Domains (1) summary
      PRK09414
      Location:3 → 451
      PRK09414; NADP-specific glutamate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07262.2

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