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    MSC6 Msc6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854536, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSC6
    Official Full Name
    Msc6p
    Primary source
    SGD:S000005881
    Locus tag
    YOR354C
    See related
    AllianceGenome:SGD:S000005881; FungiDB:YOR354C; VEuPathDB:YOR354C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in mitochondrial translational initiation and reciprocal meiotic recombination. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSC6 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (1001147..1003225, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene TFIIH complex subunit TFB6 Neighboring gene Sog2p Neighboring gene Gds1p Neighboring gene putative electron-transferring-flavoprotein dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA(fMet). Franco LVR, et al. FEBS J, 2019 Apr. PMID 30767393
    2. Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p. Moda BS, et al. Curr Genet, 2016 Aug. PMID 26780366
    3. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson DA, et al. Genetics, 1999 Oct. PMID 10511544, Free PMC Article
    4. Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes. Tutaj H, et al. Curr Genet, 2019 Apr. PMID 30244280, Free PMC Article
    5. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Lin YY, et al. Cell, 2009 Mar 20. PMID 19303850, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Msc6p
    NP_014999.1
    • Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      1001147..1003225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183774.1 → NP_014999.1  TPA: Msc6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W349, Q08818
      UniProtKB/TrEMBL
      B3LK11, N1NZ02
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08818.1

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