ABP140 tRNA(Thr) (cytosine(32)-N(3))-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ABP140
Official Full Name: tRNA(Thr) (cytosine(32)-N(3))-methyltransferase
Primary source: SGD:S000005765
Locus tag: YOR239W
See related: AllianceGenome:SGD:S000005765; FungiDB:YOR239W; VEuPathDB:YOR239W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: TRM140; YOR240W
Summary: Enables actin filament binding activity; protein-macromolecule adaptor activity; and tRNA (cytidine-3-)-methyltransferase activity. Involved in tRNA methylation. Located in actin filament and actin filament bundle. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine) and METTL2B (methyltransferase 2B, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (cytidine-3-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-3-)-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA (cytidine-3-)-methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in actin filament bundle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in mating projection tip	HDA more info	PubMed

NP_014882.4

AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift

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The following sections contain reference sequences that belong to a specific genome build. Explain