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    MSA1 Msa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSA1
    Official Full Name
    Msa1p
    Primary source
    SGD:S000005592
    Locus tag
    YOR066W
    See related
    AllianceGenome:SGD:S000005592; FungiDB:YOR066W; VEuPathDB:YOR066W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YOR29-17
    Summary
    Involved in G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (449436..451325)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Yng1p Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit CYT1 Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene Vam10p Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae MSA1 mRNA has a sequence for localization at the bud tip. Takeuchi-Andoh T, et al. Biosci Biotechnol Biochem, 2017 Sep. PMID 28693383
    2. Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress. González-Novo A, et al. Mol Cell Biol, 2015 May. PMID 25733686, Free PMC Article
    3. The transcription factors Tec1 and Ste12 interact with coregulators Msa1 and Msa2 to activate adhesion and multicellular development. van der Felden J, et al. Mol Cell Biol, 2014 Jun. PMID 24732795, Free PMC Article
    4. The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae. Ashe M, et al. J Biol Chem, 2008 Mar 7. PMID 18160399
    5. Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants. Li JM, et al. Cell Cycle, 2008 Nov 1. PMID 18948746

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a regulatory mechanism for Msa1p through the localized control of MSA1 mRNA
      Title: Saccharomyces cerevisiae MSA1 mRNA has a sequence for localization at the bud tip.
    2. Hog1 interacts with and phosphorylates components of the core cell cycle transcriptional machinery such as Whi5 and the coregulator Msa1. Phosphorylation of these two transcriptional regulators by Hog1 is essential for inhibition of G1 cyclin expression.
      Title: Hog1 targets Whi5 and Msa1 transcription factors to downregulate cyclin expression upon stress.
    3. MSA1 is a high copy suppressor of a drc1-1 mutant.
      Title: Identification of MSA1, a cell cycle-regulated, dosage suppressor of drc1/sld2 and dpb11 mutants.
    4. Msa1 acts to advance the timing of G(1)-specific transcription and cell cycle initiation
      Title: The SBF- and MBF-associated protein Msa1 is required for proper timing of G1-specific transcription in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G1/S transition of mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Msa1p
    NP_014709.1
    • Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      449436..451325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183485.1 → NP_014709.1  TPA: Msa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014709.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2C9, O00026, Q08471
      UniProtKB/TrEMBL
      G2WMU4, N1NVR7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08471.1

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