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    SDH5 succinate dehydrogenase assembly factor SDH5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDH5
    Official Full Name
    succinate dehydrogenase assembly factor SDH5
    Primary source
    SGD:S000005432
    Locus tag
    YOL071W
    See related
    AllianceGenome:SGD:S000005432; FungiDB:YOL071W; VEuPathDB:YOL071W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EMI5
    Summary
    Involved in mitochondrial respiratory chain complex II assembly; protein flavinylation; and tricarboxylic acid cycle. Located in mitochondrion. Is active in mitochondrial matrix. Used to study paraganglioma. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDH5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (196507..196995)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dsc2p Neighboring gene Thp1p Neighboring gene Nba1p Neighboring gene kinetochore-associated Ndc80 complex subunit NUF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site. Eletsky A, et al. Biochemistry, 2012 Oct 30. PMID 23062074, Free PMC Article
    2. Complete Native Stable Isotope Labeling by Amino Acids of Saccharomyces cerevisiae for Global Proteomic Analysis. Dannenmaier S, et al. Anal Chem, 2018 Sep 4. PMID 30102515, Free PMC Article
    3. Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit. Kim HJ, et al. J Biol Chem, 2012 Nov 23. PMID 23043141, Free PMC Article
    4. Emerging concepts in the flavinylation of succinate dehydrogenase. Kim HJ, et al. Biochim Biophys Acta, 2013 May. PMID 23380393, Free PMC Article
    5. Pseudomonas-Saccharomyces interactions: influence of fungal metabolism on bacterial physiology and survival. Romano JD, et al. J Bacteriol, 2005 Feb. PMID 15659672, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studies indicate that the flavinylation factor Sdh5 provided insight into the possible mechanism associated with Sdh1 flavinylation.
      Title: Emerging concepts in the flavinylation of succinate dehydrogenase.
    2. The NMR structure of Sdh5 represents the first eukaryotic structure of Pfam family PF03937 and reveals a conserved surface region, which likely represents a putative Sdh1-Sdh5 interaction interface.
      Title: Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.
    3. Sdh5 (originally named EMI5/YOL071W)is required for succinate dehydrogenase(SDH)-dependent respiration and for Sdh1 flavination
      Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascospore formation HMP PubMed 
    involved_in mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein flavinylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase assembly factor SDH5
    NP_014570.1
    • Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      196507..196995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183326.1 → NP_014570.1  TPA: succinate dehydrogenase assembly factor SDH5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZND9, B3LIY9, D6W1Z6, Q08230
      UniProtKB/TrEMBL
      C7GK38, C8ZHP4, G2WMG3, N1NXN8
      Conserved Domains (1) summary
      COG2938
      Location:52 → 150
      SdhE; Succinate dehydrogenase flavin-adding protein, antitoxin component of the CptAB toxin-antitoxin module [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08230.1

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