Chro Chromator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Chroprovided by FlyBase
Official Full Name: Chromatorprovided by FlyBase
Primary source: FLYBASE:FBgn0044324
Locus tag: Dmel_CG10712
See related: AllianceGenome:FB:FBgn0044324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2E3; CG10712; Chiz; Chr; Chriz; CHRIZ; Chriz-WR; CHRIZ/CHRO; chro; CHRO; Chro(Chriz); CHRO/CHRIZ; Dmel\CG10712; MRG15
Summary: Enables histone binding activity. Involved in several processes, including metaphase chromosome alignment; mitotic spindle assembly checkpoint signaling; and mitotic spindle organization. Located in chromosome; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut; embryonic/larval salivary gland; and energid. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 80B1-80B2; 3-47 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (22873702..22878984, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (22866802..22872084, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
Title: The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.
The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
Title: The Chriz Protein Promotes the Recruitment of the Z4 Protein to the STAT-Dependent Promoters.
Preliminary data have been obtained showing that ectopically tethered Chromator to the band 10A1-2 can induce a partial decompactization of the band chromatin.
Title: ECTOPIC TETHERING OF THE CHROMATOR PROTEIN IN UASDBD(GAL4) SYSTEM AS APPROACH FOR STUDYING OF THE INSULATOR PROTEINS IN DROSOPHILA MELANOGASTER POLYTENE CHROMOSOMES.
CHRO role in the decompaction of condensed bands in the Drosophila melanogaster polytene chromosomes and replication timing
Title: Tethering of CHROMATOR and dCTCF proteins results in decompaction of condensed bands in the Drosophila melanogaster polytene chromosomes but does not affect their transcription and replication timing.
Data show that the spindle matrix complex, including Chromator/Chriz (Chro), Megator (Mtor), and enhanced adult sensory threshold (East), has a novel nuclear function in reactivation of neural stem cells (NSCs).
Title: An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins.
interaction between Chriz and Mod(mdg4) protein
Title: Chromator protein directly interacts with the common part of the Drosophila melanogaster Mod(mdg4) family proteins.
The chromodomain-containing NH(2)-terminus of Chromator interacts with histone H1 and is required for correct targeting to chromatin.
Title: The chromodomain-containing NH(2)-terminus of Chromator interacts with histone H1 and is required for correct targeting to chromatin.
Chriz and zinc-finger protein Z4 form a complex that recruits the JIL-1 kinase to polytene chromosomes, enabling local H3S10 phosphorylation of interband nucleosomal histones.
Title: The Chriz-Z4 complex recruits JIL-1 to polytene chromosomes, a requirement for interband-specific phosphorylation of H3S10.
Expression of full-length Chromator transgene under endogenous promoter control restored both microtubule spindle morphology as well as brain size strongly indicating that the observed mutant defect were directly attributable to lack of Chromator function
Title: Chromator is required for proper microtubule spindle formation and mitosis in Drosophila.
Chro activates and east inhibits processes and genes involved in tissue destruction and remodeling.
Title: EAST and Chromator control the destruction and remodeling of muscles during Drosophila metamorphosis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c22875069-22874925 mobile_element_type = transposon:INE-1{}2641

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in metamorphosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: chromator

Names: CG10712-PA; CG10712-PB; CG10712-PC; CG10712-PD; CG10712-PE; Chro-PA; Chro-PB; Chro-PC; Chro-PD; Chro-PE; anon-fast-evolving-2E3; chromo domain protein interacting with Z4; chromobox protein interacting with Z4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

22873702..22878984 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300221.1 → NP_001287150.1 chromator, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287150.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS3, Q8T9D1

Conserved Domains (1) summary

cd00024
Location:219 → 273

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_168976.2 → NP_730763.2 chromator, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730763.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS3, Q8T9D1

Conserved Domains (1) summary

cd00024
Location:219 → 273

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_168975.2 → NP_730762.2 chromator, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730762.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS3, Q8T9D1

Conserved Domains (1) summary

cd00024
Location:219 → 273

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_001275297.1 → NP_001262226.1 chromator, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262226.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS3, Q8T9D1

Conserved Domains (1) summary

cd00024
Location:219 → 273

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
NM_141169.3 → NP_649426.3 chromator, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649426.3

Status: REVIEWED

UniProtKB/TrEMBL

Q86BS3, Q8T9D1

Related

FBpp0078221

Conserved Domains (1) summary

cd00024
Location:219 → 273

CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...