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    NSG2 Nsg2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NSG2
    Official Full Name
    Nsg2p
    Primary source
    SGD:S000005100
    Locus tag
    YNL156C
    See related
    AllianceGenome:SGD:S000005100; FungiDB:YNL156C; VEuPathDB:YNL156C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in sterol biosynthetic process. Located in endoplasmic reticulum. Orthologous to human INSIG1 (insulin induced gene 1) and INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NSG2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (341069..341968, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pga1p Neighboring gene phosphatase regulator Neighboring gene uncharacterized protein Neighboring gene Cuz1p Neighboring gene serine/threonine protein kinase YCK2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. Theesfeld CL, et al. J Biol Chem, 2013 Mar 22. PMID 23306196, Free PMC Article
    2. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, et al. EMBO J, 2005 Nov 16. PMID 16270032, Free PMC Article
    3. Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance. Sardi M, et al. PLoS Genet, 2018 Feb. PMID 29474395, Free PMC Article
    4. Uptake of inorganic phosphate is a limiting factor for Saccharomyces cerevisiae during growth at low temperatures. Vicent I, et al. FEMS Yeast Res, 2015 May. PMID 25725023
    5. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nsg2p
    NP_014243.3
    • Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      341069..341968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182994.3 → NP_014243.3  TPA: Nsg2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014243.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W127, P53898
      UniProtKB/TrEMBL
      A6ZRS8, B3LP11, B5VQP8, C7GXV6, C8ZG73, N1NXD0
      Conserved Domains (1) summary
      pfam07281
      Location:116 → 296
      INSIG; Insulin-induced protein (INSIG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53898.1

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