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    CRS1 cysteine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CRS1
    Official Full Name
    cysteine--tRNA ligase
    Primary source
    SGD:S000005191
    Locus tag
    YNL247W
    See related
    AllianceGenome:SGD:S000005191; FungiDB:YNL247W; VEuPathDB:YNL247W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cysteine-tRNA ligase activity and sequence-specific mRNA binding activity. Involved in cysteinyl-tRNA aminoacylation. Located in cytosol and mitochondrion. Used to study microcephaly. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CRS1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (182875..185178)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mpa43p Neighboring gene DNA-directed RNA polymerase I subunit RPA49 Neighboring gene Vps75p Neighboring gene U2-type spliceosomal complex subunit CWC25 Neighboring gene translation initiation factor eIF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of the L-cysteinyl ribonucleic acid synthetase of bakers' yeast. James HL, et al. J Biol Chem, 1969 Jun 25. PMID 4307312
    2. A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation. Hoffman KS, et al. J Biol Chem, 2019 Aug 23. PMID 31296657, Free PMC Article
    3. Cysteinyl-tRNA synthetase from Saccharomyces cerevisiae. Purification, characterization and assignment to the genomic sequence YNL247w. Motorin Y, et al. Biochimie, 1997 Dec. PMID 9523015
    4. Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase. Lipman RS, et al. Proc Natl Acad Sci U S A, 1998 Nov 10. PMID 9811828, Free PMC Article
    5. Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells. Nishimura A, et al. J Biol Chem, 2019 Sep 13. PMID 31350340, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteinyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine--tRNA ligase
    NP_014152.1
    • Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      182875..185178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183085.1 → NP_014152.1  TPA: cysteine--tRNA ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014152.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0U6, P53852
      UniProtKB/TrEMBL
      G2WLL9
      Conserved Domains (1) summary
      PTZ00399
      Location:2 → 762
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53852.1

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