ADE17 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADE17
Official Full Name: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17
Primary source: SGD:S000004727
Locus tag: YMR120C
See related: AllianceGenome:SGD:S000004727; FungiDB:YMR120C; VEuPathDB:YMR120C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADE17 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (507502..509280, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables IMP cyclohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IMP cyclohydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP cyclohydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	IEA Inferred from Electronic Annotation more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' IMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' IMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17

NP_013839.1

EC 2.1.2.3

EC 3.5.4.10

Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

507502..509280 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182621.1 → NP_013839.1 TPA: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013839.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZU3, P38009

UniProtKB/TrEMBL

A6ZMI0, B3LM11, B5VPP5, C7GU98, C8ZEX4, N1P0C5

Conserved Domains (1) summary

TIGR00355
Location:6 → 546

purH; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase