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    SRC1 Src1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRC1
    Official Full Name
    Src1p
    Primary source
    SGD:S000004497
    Locus tag
    YML034W
    See related
    AllianceGenome:SGD:S000004497; FungiDB:YML034W; VEuPathDB:YML034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HEH1; YML033W
    Summary
    Predicted to enable chromatin binding activity. Involved in establishment of mitotic sister chromatid cohesion; maintenance of rDNA; and mitotic sister chromatid segregation. Located in nuclear envelope. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRC1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    2
    Sequence:
    Chromosome: XIII; NC_001145.3 (209525..212155)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cgi121p Neighboring gene AMP deaminase Neighboring gene recombinase RAD52 Neighboring gene Ndc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
      Title: ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing.
    2. Chm7 recruitment to sites of nuclear pore complexes assembly is mediated by its ESCRT-II domain and the LAP2-emerin-MAN1 (LEM) family of integral inner nuclear membrane proteins, Heh1 and Heh2.
      Title: Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing.
    3. Heh2 and Src1/Heh1 contain bipartite import sequences that associate intimately with the minor nuclear localization sequence-binding pocket of yeast importin alpha.
      Title: Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
    4. Heh1p has a role in the assembly or stability of the nuclear pore complexes, potentially through the formation of a lumenal bridge with Pom152p.
      Title: Lumenal interactions in nuclear pore complex assembly and stability.
    5. The inner nuclear membrane protein Src1 functions at the interface between subtelomeric gene expression and TREX-dependent messenger RNA export through the nuclear pore complexes.
      Title: The inner nuclear membrane protein Src1 associates with subtelomeric genes and alters their regulated gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nuclear membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    is_active_in nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Src1p
    NP_013679.1
    • Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      209525..212155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182391.1 → NP_013679.1  TPA: Src1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZE1, Q03707, Q03712
      UniProtKB/TrEMBL
      A6ZM29, B3LLL9, C7GT63
      Conserved Domains (2) summary
      cd12935
      Location:14 → 48
      LEM_like; LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins
      pfam09402
      Location:464 → 820
      MSC; Man1-Src1p-C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03707.2

    Gene LinkOut

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