U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FPR3 peptidylprolyl isomerase FPR3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854901, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FPR3
    Official Full Name
    peptidylprolyl isomerase FPR3
    Primary source
    SGD:S000004539
    Locus tag
    YML074C
    See related
    AllianceGenome:SGD:S000004539; FungiDB:YML074C; VEuPathDB:YML074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NPI46
    Summary
    Enables macrolide binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in meiotic recombination checkpoint signaling and nucleosome assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FPR3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (120089..121324, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene War1p Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Neighboring gene ribosomal 60S subunit protein L6A Neighboring gene Tcb3p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1. Wilson LK, et al. J Biol Chem, 1995 Oct 20. PMID 7559654
    2. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. Shan X, et al. J Cell Biol, 1994 Aug. PMID 8051210, Free PMC Article
    3. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Hochwagen A, et al. Cell, 2005 Sep 23. PMID 16179256
    4. Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures. Utsugi T, et al. Gene, 1999 Jul 8. PMID 10395901
    5. Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription. Park SK, et al. Mol Genet Genomics, 2014 Apr. PMID 24297734

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report show that Fpr3 regulates Cse4 proteolysis and the structural changes in CSe4 might be important for its interaction with Psh1.
      Title: Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
    2. The results thus provide a further demonstration for the elusive role of Fpr3 and Fpr4 in histone chaperones.
      Title: Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription.
    3. The FK506 binding protein Fpr3 prevents premature adaptation to damage and thus serves to maintain recombination checkpoint activity.
      Title: The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables macrolide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic recombination checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic recombination checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    peptidylprolyl isomerase FPR3
    NP_013637.1
    • Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      120089..121324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182433.1 → NP_013637.1  TPA: peptidylprolyl isomerase FPR3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0K9, P38911
      UniProtKB/TrEMBL
      G2WJY1, N1NYY3
      Conserved Domains (2) summary
      COG0545
      Location:287 → 410
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam17800
      Location:118 → 162
      NPL; Nucleoplasmin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38911.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools