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    SNR6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 9164922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNR6
    Primary source
    SGD:S000006494
    Locus tag
    YNCL0006W
    See related
    AllianceGenome:SGD:S000006494
    Gene type
    ncRNA
    RNA name
    snRNA
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables snRNA binding activity. Involved in RNA secondary structure unwinding; generation of catalytic spliceosome for second transesterification step; and spliceosome conformational change to release U4 (or U4atac) and U1 (or U11). Part of U4/U6 x U5 tri-snRNP complex and U6 snRNP. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNR6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (366235..366346)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene AAA family ATPase midasin Neighboring gene RNA exonuclease Neighboring gene uncharacterized protein Neighboring gene thioredoxin peroxidase AHP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome. Bao P, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30335160, Free PMC Article
    2. Structure of the U6 RNA intramolecular stem-loop harboring an S(P)-phosphorothioate modification. Reiter NJ, et al. RNA, 2003 May. PMID 12702812, Free PMC Article
    3. Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Yean SL, et al. Nature, 2000 Dec 14. PMID 11130730, Free PMC Article
    4. Disruption of the 5' stem-loop of yeast U6 RNA induces trimethylguanosine capping of this RNA polymerase III transcript in vivo. Kwan S, et al. RNA, 2000 Dec. PMID 11142384, Free PMC Article
    5. The intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loop. Shukla GC, et al. RNA, 2001 Jan. PMID 11214185, Free PMC Article

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    • U6 spliceosomal RNA (U6 snRNA); mediates catalysis of pre-mRNA splicing by the spliceosome; interacts with U4; homology to U6 snRNA, interacts with snr14

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U4 snRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables snRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA secondary structure unwinding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in generation of catalytic spliceosome for second transesterification step IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal tri-snRNP complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of U6 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      366235..366346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_132206.1 RNA Sequence

      Status: REVIEWED

    Gene LinkOut

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    Research Materials