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    LSM3 U4/U6-U5 snRNP complex subunit LSM3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LSM3
    Official Full Name
    U4/U6-U5 snRNP complex subunit LSM3
    Primary source
    SGD:S000006434
    Locus tag
    YLR438C-A
    See related
    AllianceGenome:SGD:S000006434; FungiDB:YLR438C-A; VEuPathDB:YLR438C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SMX4; USS2
    Summary
    Contributes to RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleolus. Part of Lsm1-7-Pat1 complex; sno(s)RNA-containing ribonucleoprotein complex; and spliceosomal snRNP complex. Orthologous to human LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LSM3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (1013909..1014178, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Dif1p Neighboring gene ornithine-oxo-acid transaminase Neighboring gene mitochondrial 54S ribosomal protein YmL4 Neighboring gene Sec39p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A complex pathway for 3' processing of the yeast U3 snoRNA. Kufel J, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627812, Free PMC Article
    2. Homomeric ring assemblies of eukaryotic Sm proteins have affinity for both RNA and DNA. Crystal structure of an oligomeric complex of yeast SmF. Collins BM, et al. J Biol Chem, 2003 May 9. PMID 12618433
    3. A conditional U5 snRNA mutation affecting pre-mRNA splicing and nuclear pre-mRNA retention identifies SSD1/SRK1 as a general splicing mutant suppressor. Luukkonen BG, et al. Nucleic Acids Res, 1999 Sep 1. PMID 10446233, Free PMC Article
    4. Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. Naidoo N, et al. J Mol Biol, 2008 Apr 11. PMID 18329667
    5. Characterization of U6 snRNA-protein interactions. Vidal VP, et al. RNA, 1999 Nov. PMID 10580475, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
      Title: Growth-regulated co-occupancy of Mediator and Lsm3 at intronic ribosomal protein genes.
    2. The N-terminal helix of Lsm3 intreacting with the structure of the C-terminal domain of Pat1 suggests a potential mechanism for RNA binding that involves the helix and loop faces of the Lsm1-7 ring.
      Title: Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation.
    3. The Lsm3 structure thus provides evidence for protein-protein interactions likely utilised by the highly variable Lsm loops and termini in the recruitment of RNA processing factors to mixed Lsm ring scaffolds.
      Title: Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Lsm1-7-Pat1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Lsm1-7-Pat1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sm-like protein family complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U6 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U6 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit LSM3
    NP_013543.3
    • Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      1013909..1014178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184308.3 → NP_013543.3  TPA: U4/U6-U5 snRNP complex subunit LSM3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013543.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ73, P57743, Q05176, Q06759
      UniProtKB/TrEMBL
      A7A1V8, B3RHU7, C7GSL7, C8ZE46, G2WJP9, N1NYV8
      Conserved Domains (1) summary
      cd01730
      Location:4 → 78
      LSm3; Like-Sm protein 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P57743.1

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