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    IGO2 phosphatase regulator [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IGO2
    Official Full Name
    phosphatase regulator
    Primary source
    SGD:S000007496
    Locus tag
    YHR132W-A
    See related
    AllianceGenome:SGD:S000007496; FungiDB:YHR132W-A; VEuPathDB:YHR132W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase inhibitor activity. Involved in cellular response to heat; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of cell cycle process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IGO2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (370054..370449)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene putative metallocarboxypeptidase Neighboring gene Nsg1p Neighboring gene metalloendopeptidase WSS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantification of mRNA stability of stress-responsive yeast genes following conditional excision of open reading frames. Talarek N, et al. RNA Biol, 2013 Aug. PMID 23792549, Free PMC Article
    2. A phosphatase-centric mechanism drives stress signaling response. Hollenstein DM, et al. EMBO Rep, 2021 Nov 4. PMID 34558777, Free PMC Article
    3. The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast. Sarkar S, et al. PLoS Genet, 2014 Jun. PMID 24968058, Free PMC Article
    4. Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs. Luo X, et al. RNA Biol, 2011 Jan-Feb. PMID 21289492
    5. Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Bontron S, et al. Cell Rep, 2013 Jan 31. PMID 23273919

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of Igo2 with PP2A(Cdc55) is regulated during the cell cycle, yet mutation of Pkc1-dependent phosphorylation sites on Cdc55 and Igo2 did not cause defects in mitotic progression.
      Title: Protein Kinase C Controls Binding of Igo/ENSA Proteins to Protein Phosphatase 2A in Budding Yeast.
    2. We propose that the Rim15-Endosulfine( Igo1 and Igo2 )-PP2ACdc55 signalling module triggers entry into quiescence and gametogenesis by regulating dephosphorylation of distinct substrates.
      Title: The Rim15-endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast.
    3. Igo1/Igo2 can inhibit Cdc55 in early mitosis, but their contribution to Cdc55 regulation is relatively minor compared with the role of Zds1/Zds2.
      Title: Comparative genetic analysis of PP2A-Cdc55 regulators in budding yeast.
    4. We conclude that Greatwall, endosulfines, and PP2A are part of a regulatory module that has been conserved during evolution irrespective of PP2A function in the control of mitosis
      Title: Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.
    5. The mRNA decapping pathway targets heat shock protein 26 (HSP26) mRNAs in the absence of Igo1 and Igo2.
      Title: Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of G1 to G0 transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic cell cycle phase transition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase regulator
    NP_036194.1
    • Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S64) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo1p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      370054..370449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184441.1 → NP_036194.1  TPA: phosphatase regulator [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_036194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL81, Q9P305
      UniProtKB/TrEMBL
      A6ZT40, B3LSP6, C8Z9S7, G2WFK5, N1P164
      Conserved Domains (1) summary
      pfam04667
      Location:26 → 105
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P305.3

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