timeout timeout [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: timeoutprovided by FlyBase
Official Full Name: timeoutprovided by FlyBase
Primary source: FLYBASE:FBgn0038118
Locus tag: Dmel_CG7855
See related: AllianceGenome:FB:FBgn0038118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14381; CG14382; CG7855; CG8148; Dmel\CG7855; dtim2; tim; Tim-2; tim2; TIM2
Summary: Predicted to enable DNA binding activity. Involved in DNA damage checkpoint signaling and entrainment of circadian clock. Predicted to be part of replication fork protection complex. Is expressed in several structures, including CNS glial cell; antennal anlage; ganglia; head epidermis primordium; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13088651..13163876)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8914373..8989598)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila timeless2 is required for chromosome stability and circadian photoreception.
Title: Drosophila timeless2 is required for chromosome stability and circadian photoreception.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork arrest	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of replication fork protection complex	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain