U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyp12a5 Cytochrome P450 12a5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42293, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cyp12a5provided by FlyBase
    Official Full Name
    Cytochrome P450 12a5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038680
    Locus tag
    Dmel_CG11821
    See related
    AllianceGenome:FB:FBgn0038680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    12a5; CG11821; Cyp12A5; CYP12a5; CYP12A5; Dmel\CG11821
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic/larval Malpighian tubule; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cyp12a5 in Genome Data Viewer
    Location:
    91F2-91F3; 3-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19132648..19134704)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14958370..14960426)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ATP synthase, subunit D Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12a4 Neighboring gene Phosphopantothenoylcysteine synthetase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster. Harrop TW, et al. Pest Manag Sci, 2018 Jul. PMID 29316188
    2. Expression of Cyp6g1 and Cyp12d1 in DDT resistant and susceptible strains of Drosophila melanogaster. Festucci-Buselli RA, et al. Insect Mol Biol, 2005 Jan. PMID 15663776
    3. Gene Regulatory Variation in Drosophila melanogaster Renal Tissue. Glaser-Schmitt A, et al. Genetics, 2018 Sep. PMID 29976765, Free PMC Article
    4. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16120680, Free PMC Article
    5. SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. Vorobyeva NE, et al. Cell Cycle, 2011 Jun 1. PMID 21519192

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome P450 12a5
    Names
    CG11821-PA
    Cyp12a5-PA
    cytochrome P450
    NP_650782.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19132648..19134704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142525.4 → NP_650782.1  cytochrome P450 12a5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650782.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6SEI2, Q8MQI5, Q9VE01
      Related
      FBpp0083144
      Conserved Domains (1) summary
      pfam00067
      Location:81 → 531
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE01.1 Q9VE01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools